{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:40:50Z","timestamp":1777916450557,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Transforming growth factor-beta1 (TGF-\u03b21) may participate in local chronic inflammatory processes in varicose veins and in venous wall structure modifications through regulation of matrix metalloproteinases (MMP) and their inhibitors (tissue inhibitor of metalloproteinase (TIMP)). The aim of this study was to analyze the effect of TGF-\u03b21 in the vein wall, namely on the gene expression of selected MMP, TIMP and TGF-\u03b21 receptors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Healthy vein samples were harvested from eight subjects who underwent coronary bypass graft surgery with great saphenous vein. Each vein sample was divided into two segments, which were cultivated separately in\u00a0vitro (one of the segments had TGF-\u03b21 added) and then submitted to gene expression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the TGF-\u03b21 supplemented group, there was a general increase in the mean gene expression. Specifically, expression of MMP9, MMP12, TIMP1 and TIMP2 were statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study demonstrate that the gene expression of MMP9, MMP12, TIMP1 and TIMP2 was influenced by the addition of TGF-\u03b21. These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-\u03b21 in the vein wall pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0268355516655067","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T17:09:43Z","timestamp":1466615383000},"page":"334-341","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of TGF-beta1 on MMP\/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency"],"prefix":"10.1177","volume":"32","author":[{"given":"Pedro","family":"Serralheiro","sequence":"first","affiliation":[{"name":"Department of General Surgery, Norfolk and Norwich University Hospital, UK"},{"name":"Faculdade de Ci\u00eancias da Sa\u00fade, University of Beira Interior, Portugal"}]},{"given":"Elisa","family":"Cairr\u00e3o","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade, University of Beira Interior, Portugal"}]},{"given":"Cl\u00e1udio J","family":"Maia","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade, University of Beira Interior, Portugal"}]},{"given":"Marina","family":"Jo\u00e3o","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade, University of Beira Interior, Portugal"}]},{"given":"Carlos M Costa","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Coimbra University Hospital Centre, Portugal"},{"name":"Faculdade de Medicina, University of Coimbra, Portugal"}]},{"given":"Ignacio","family":"Verde","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade, University of Beira Interior, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"key":"bibr1-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006898"},{"key":"bibr2-0268355516655067","first-page":"439","volume":"45","author":"Da Silva A","year":"1992","journal-title":"Phlebologie"},{"key":"bibr3-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2007.03.011"},{"key":"bibr4-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.10.038"},{"key":"bibr5-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(98)80039-7"},{"key":"bibr6-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.119503"},{"key":"bibr7-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.05.012"},{"key":"bibr8-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)00134-4"},{"key":"bibr9-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)94267-5"},{"key":"bibr10-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"bibr11-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70054-6"},{"key":"bibr12-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.326"},{"key":"bibr13-0268355516655067","first-page":"542","volume":"48","author":"Kowalewski R","year":"2010","journal-title":"Folia Histochem Cytobiol"},{"key":"bibr14-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.008"},{"key":"bibr15-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70214-4"},{"key":"bibr16-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00625-6"},{"key":"bibr17-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21007"},{"key":"bibr18-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/635912"},{"key":"bibr19-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-010-9284-4"},{"key":"bibr20-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.05.022"},{"key":"bibr21-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2001.090503.x"},{"key":"bibr22-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6798"},{"key":"bibr23-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.07.026"},{"key":"bibr24-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.07.003"},{"key":"bibr25-0268355516655067","author":"de Franciscis S","year":"2015","journal-title":"Int Wound J\u2013"},{"key":"bibr26-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.04.022"},{"key":"bibr27-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12181"},{"key":"bibr28-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02449.x"},{"key":"bibr29-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(98)00020-2"},{"key":"bibr30-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3073"},{"key":"bibr31-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.12.044"},{"key":"bibr32-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00015.2014"},{"key":"bibr33-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1273rev"},{"key":"bibr34-0268355516655067","first-page":"82","volume":"144","author":"Marti HP","year":"1994","journal-title":"Am J Pathol"},{"key":"bibr35-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1177\/00033197050560i103"},{"key":"bibr36-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1159\/000100375"},{"key":"bibr37-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12977"},{"key":"bibr38-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.10.010"},{"key":"bibr39-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1177\/0003319701052001S04"},{"key":"bibr40-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01641.x"},{"key":"bibr41-0268355516655067","first-page":"11","volume":"375","author":"Zhang H","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"bibr42-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH670>3.0.CO;2-1"},{"key":"bibr43-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6455"},{"key":"bibr44-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000200"},{"key":"bibr45-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027521.83518.4C"},{"key":"bibr46-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-003-0005-2"},{"key":"bibr47-0268355516655067","first-page":"164","volume":"23","author":"Kowalewski R","year":"2004","journal-title":"Int Angiol"},{"key":"bibr48-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70093-X"},{"key":"bibr49-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060170"},{"key":"bibr50-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1159\/000025573"},{"key":"bibr51-0268355516655067","doi-asserted-by":"publisher","DOI":"10.1159\/000087314"}],"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0268355516655067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0268355516655067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0268355516655067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:48:22Z","timestamp":1777657702000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0268355516655067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,20]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1177\/0268355516655067"],"URL":"https:\/\/doi.org\/10.1177\/0268355516655067","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"value":"0268-3555","type":"print"},{"value":"1758-1125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,20]]}}}