{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:01:44Z","timestamp":1767898904477,"version":"3.49.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p> The impact of physiological stressors on cerebral sympathetic nervous activity (SNA) remains controversial. We hypothesized that cerebral noradrenaline (NA) spillover, an index of cerebral SNA, would not change during both submaximal isometric handgrip (HG) exercise followed by a post-exercise circulatory occlusion (PECO), and supine dynamic cycling exercise. Twelve healthy participants (5 females) underwent simultaneous blood sampling from the right radial artery and right internal jugular vein. Right internal jugular vein blood flow was measured using Duplex ultrasound, and tritiated NA was infused through the participants' right superficial forearm vein. Heart rate was recorded via electrocardiogram and blood pressure was monitored using the right radial artery. Total NA spillover increased during HG (P\u2009=\u20090.049), PECO (P\u2009=\u20090.006), and moderate cycling exercise (P\u2009=\u20090.03) compared to rest. Cerebral NA spillover remained unchanged during isometric HG exercise (P\u2009=\u20090.36), PECO after the isometric HG exercise (P\u2009=\u20090.45), and during moderate cycling exercise (P\u2009=\u20090.94) compared to rest. These results indicate that transient increases in blood pressure during acute exercise involving both small and large muscle mass do not engage cerebral SNA in healthy humans. Our findings suggest that cerebral SNA may be non-obligatory for exercise-related cerebrovascular adjustments. <\/jats:p>","DOI":"10.1177\/0271678x241248228","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T07:38:30Z","timestamp":1712993910000},"page":"1840-1851","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Acute isometric and dynamic exercise do not alter cerebral sympathetic nerve activity in healthy humans"],"prefix":"10.1177","volume":"44","author":[{"given":"Michael M","family":"Tymko","sequence":"first","affiliation":[{"name":"Integrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Canada"},{"name":"Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, 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Canada"}]},{"given":"Sarah","family":"Imhoff","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec, Canada"}]},{"given":"Geoff B","family":"Coombs","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Science, McMaster University, Hamilton, Canada"}]},{"given":"Stephan","family":"Langevin","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec, Canada"}]},{"given":"Marc","family":"Fortin","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec-Universit\u00e9 Laval, Qu\u00e9bec, Canada"}]},{"given":"Nathalie","family":"Ch\u00e2teauvert","sequence":"additional","affiliation":[{"name":"Institut 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