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We assessed dynamic cerebral autoregulation (dCA), vasoreactivity to carbon dioxide, and neurovascular coupling (NVC) in the middle (MCA) and posterior (PCA) cerebral arteries of 52 patients. Neuropsychological evaluation included the Montreal Cognitive Assessment and tests covering attention, executive function, processing speed, and memory. Notably, reduced rate time in the PCA significantly predicted better processing speed ( p\u2009=\u20090.003). Furthermore, reduced overshoot systolic cerebral blood velocity in the PCA and reduced phase in the VLF range in the MCA ( p\u2009=\u20090.021 and p\u2009=\u20090.017, respectively) significantly predicted better memory. Intriguingly, enhanced dCA in the MCA predicted poorer memory performance, while reduced NVC in the PCA predicted both superior processing speed and memory performance. These findings suggest that HT-induced changes in cerebral hemodynamics impact cognitive performance. Further research should verify these observations and elucidate whether these changes represent adaptive responses or neurovascular inefficiency. TCD markers might provide insights into HT-related cognitive decline.<\/jats:p>","DOI":"10.1177\/0271678x241254680","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:49:06Z","timestamp":1715579346000},"page":"1277-1287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Cerebral blood flow regulation and cognitive performance in hypertension"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-2556","authenticated-orcid":false,"given":"Ana","family":"Monteiro","sequence":"first","affiliation":[{"name":"UnIC@RISE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto, Porto, Portugal"},{"name":"Department of Neurology, Unidade Local de Sa\u00fade Alto Ave \u2013 Hospital de Guimar\u00e3es, E.P.E., Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2398","authenticated-orcid":false,"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"UnIC@RISE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto, Porto, Portugal"},{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., Porto, Portugal"}]},{"given":"Gilberto","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., Porto, Portugal"}]},{"given":"Carmen","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., Porto, Portugal"}]},{"given":"Jorge","family":"Polonia","sequence":"additional","affiliation":[{"name":"CINTESIS@RISE, Department of Medicine, Faculty of Medicine of University of Porto, Porto, Portugal"},{"name":"Hypertension and Cardiovascular Risk Unit, Unidade Local de Sa\u00fade de Matosinhos, Matosinhos, Portugal"}]},{"given":"Mariana","family":"Lobo","sequence":"additional","affiliation":[{"name":"CINTESIS@RISE, MEDCIDS Department, Faculty of Medicine of University of Porto, Porto, Portugal"}]},{"given":"Elsa","family":"Azevedo","sequence":"additional","affiliation":[{"name":"UnIC@RISE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto, Porto, Portugal"},{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., Porto, 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