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From the available animal data it is concluded that the antinociceptive effect of orphenadrine has been clearly demonstrated but data have also clearly indicated that it has muscle relaxant properties. Human placebo-controlled studies have shown some support for the view that orphenadrine on its own acts as a mild analgesic in painful conditions associated with muscle spasm. Although only a small number of well-controlled studies have been completed with the combination product of orphenadrine\/paracetamol, each supports the view that the combination has superior efficacy over paracetamol alone. There is no doubt that the combination product is more efficacious than placebo.<\/jats:p>","DOI":"10.1177\/030006059101900201","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T23:33:27Z","timestamp":1484091207000},"page":"71-87","source":"Crossref","is-referenced-by-count":33,"title":["Clinical and Pharmacological Review of the Efficacy of Orphenadrine and Its Combination with Paracetamol in Painful Conditions"],"prefix":"10.1177","volume":"19","author":[{"given":"S.","family":"Hunskaar","sequence":"first","affiliation":[{"name":"Institute of General Practice, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Donnell","sequence":"additional","affiliation":[{"name":"Medical Department, 3M Health Care Ltd, Loughborough, 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