{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T05:49:31Z","timestamp":1740980971520,"version":"3.38.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p> The efficacy and safety of single doses of 6 mg sumatriptan, self-administered subcutaneously by patients using an auto-injector, for the acute treatment of up to three successive attacks of migraine was investigated in a multicentre, open, uncontrolled study in which 178 patients were enrolled. At attack 1, there was an improvement in headache (from severe or moderate to mild or no headache) in 74% of patients at 1 h, and in 82% at 2 h. The incidence of symptoms associated with migraine was decreased after sumatriptan injection. Nausea, vomiting and photo\/phonophobia were reported by 72, 54, and 85% of patients, respectively, before the injection to treat attack 1, but by only 22, 12 and 27%, respectively, 2 h after the injection. Migraine recurred within 24 h in 27% of patients, but in 89% of patients was effectively treated with a further dose of 6 mg sumatriptan. Results for attacks 2 and 3 were similar. About 40% of patients experienced at least one adverse event; most of these were mild or moderate in intensity and were transient. It is concluded that 6 mg sumatriptan, self-administered using an auto-injector, is an effective and well tolerated treatment for migraine. Sumatriptan was as effective at attack 3 as at attack 1, and there was no evidence of a change in the incidence or the nature of adverse events with successive uses of the drug. <\/jats:p>","DOI":"10.1177\/030006059402200404","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T05:10:15Z","timestamp":1484543415000},"page":"225-235","source":"Crossref","is-referenced-by-count":1,"title":["An Open Study of Self-Administration of Subcutaneous Sumatriptan to Treat Successive Attacks of Acute Migraine"],"prefix":"10.1177","volume":"22","author":[{"given":"P","family":"Monteiro","sequence":"first","affiliation":[]},{"name":"The Portuguese Sumatriptan Auto-Injector Study Group","sequence":"additional","affiliation":[]}],"member":"179","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"bibr1-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90147-2"},{"key":"bibr2-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1992.1204229.x"},{"key":"bibr3-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480010072027"},{"key":"bibr4-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1982.0202071.x"},{"key":"bibr5-030006059402200404","first-page":"106","volume-title":"Dilemmas in the management of the neurological patient","author":"Thrush D","year":"1984"},{"key":"bibr6-030006059402200404","first-page":"173","volume-title":"Handbook of Clinical Neurology, Vol. 4","author":"Peatfield RC","year":"1986"},{"key":"bibr7-030006059402200404","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/0333102489009S1048","volume":"9","author":"Perrin VL","year":"1989","journal-title":"Cephalalgia"},{"key":"bibr8-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1159\/000116632"},{"key":"bibr9-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1159\/000116758"},{"key":"bibr10-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250504"},{"key":"bibr11-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460210077033"},{"key":"bibr12-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1159\/000116760"},{"key":"bibr13-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1159\/000116761"},{"key":"bibr14-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1991.tb00022.x"},{"key":"bibr15-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1159\/000116762"},{"key":"bibr16-030006059402200404","first-page":"157","volume":"13","author":"Hulme A","year":"1993","journal-title":"Cephalalgia"},{"key":"bibr17-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1159\/000116756"},{"key":"bibr18-030006059402200404","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(89)90046-6"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059402200404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059402200404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T18:50:25Z","timestamp":1740941425000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059402200404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1177\/030006059402200404"],"URL":"https:\/\/doi.org\/10.1177\/030006059402200404","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"type":"print","value":"0300-0605"},{"type":"electronic","value":"1473-2300"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}