{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:21:56Z","timestamp":1777918916244,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T00:00:00Z","timestamp":1285113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>Canine renal cell carcinomas (RCCs) are uncommon aggressive tumors that occur mainly in middle-aged male dogs. Their histologic classification bears no relationship with prognosis, and little information is available concerning their immunohistochemical properties. In this retrospective study, formalin-fixed, paraffin-embedded tissues from 13 canine RCCs were retrieved from the archives, classified histologically, and evaluated immunohistochemically. The dogs were 7 males and 6 females (1 spayed) of 10 different breeds, averaging 8 years in age. The tumors were classified as papillary, tubulopapillary, papillary\u2013cystic, solid, or sarcomatoid. All 13 tumors were immunohistochemically positive for uromodulin, 12 for c-KIT, 11 for vimentin, 9 for wide-spectrum-screening cytokeratins, 7 for cytokeratins AE1\/AE3 and carcinoembryonic antigen, 4 for cytokeratins CAM 5.2, and 3 for CD10. All 3 solid RCCs expressed vimentin, c-KIT, and carcinoembryonic antigen and were negative for cytokeratins. All 7 papillary and tubulopapillary tumors expressed vimentin; 6 (86%), cytokeratins; and 6 (86%), c-KIT. Both papillary\u2013cystic RCCs were positive for cytokeratins and c-KIT and negative for vimentin. These results indicate that the different histologic types of RCC have characteristic immunohistochemical profiles and that c-KIT may be involved in the pathogenesis of canine RCC.<\/jats:p>","DOI":"10.1177\/0300985810381909","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:25:34Z","timestamp":1285201534000},"page":"427-432","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Immunohistochemical Characterization of 13 Canine Renal Cell Carcinomas"],"prefix":"10.1177","volume":"48","author":[{"given":"R. M.","family":"Gil da Costa","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"}]},{"given":"J. P.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CECAV, University of Tr\u00e1s-os-Montes e Alto-Douro, Vila Real, Portugal"}]},{"given":"A. L.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Gram Laborat\u00f3rio de Anatomia Patol\u00f3gica Veterin\u00e1ria, Maia, Portugal"}]},{"given":"F.","family":"Seixas","sequence":"additional","affiliation":[{"name":"CECAV, University of Tr\u00e1s-os-Montes e Alto-Douro, Vila Real, Portugal"}]},{"given":"F.","family":"Faria","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"}]},{"given":"F.","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal"}]},{"given":"M. A.","family":"Pires","sequence":"additional","affiliation":[{"name":"CECAV, University of Tr\u00e1s-os-Montes e Alto-Douro, Vila Real, Portugal"}]},{"given":"C.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2010,9,22]]},"reference":[{"key":"bibr1-0300985810381909","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2559.2007.02900.x","volume":"52","author":"Allory Y","year":"2008","journal-title":"Histopathology"},{"key":"bibr2-0300985810381909","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200002000-00006"},{"key":"bibr3-0300985810381909","doi-asserted-by":"publisher","DOI":"10.1177\/030098587701400606"},{"key":"bibr4-0300985810381909","unstructured":"Eble JN : Renal neoplasia.\n                      In\n                      : Modern Surgical Pathology, ed. 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