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The Ki-67 index of primary tumors ( n = 96) was initially determined, and whenever possible, the Ki-67 index of regional lymph node metastasis ( n = 38) and distant metastasis ( n = 16) was also estimated. The optimal cutoff value for the Ki-67 index was determined by univariate and multivariate analysis. Ki-67 indices \u226514% were detected in 72.9% (70 of 96) of the tumors. Tumors with a Ki-67 index \u226514% were significantly associated with large size ( P = .022), poor differentiation ( P = .009), presence of necrotic areas ( P = .008), estrogen receptor-negative status ( P &lt; .0001), fHER2-negative status ( P = .003), and shorter overall survival ( P = .012). Moreover, Ki-67 expression in the primary tumor was strongly and positively correlated with both regional metastasis ( P &lt; .0001; r = 0.83) and distant metastasis ( P &lt; .0001; r = 0.83), and was significantly higher in distant metastases when compared with the primary tumor ( P = .0009). A similar correlation was also observed between regional and distant metastasis ( P &lt; .0001; r = 0.75). On the basis of the above results, the authors propose the adoption of the 14% value as the optimal cutoff for Ki-67 to identify tumors with high risk of disease progression.<\/jats:p>","DOI":"10.1177\/0300985815588606","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T23:47:15Z","timestamp":1434498435000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Ki-67 as a Prognostic Factor in Feline Mammary Carcinoma"],"prefix":"10.1177","volume":"53","author":[{"given":"M.","family":"Soares","sequence":"first","affiliation":[{"name":"CIISA, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, Lisboa, Portuga"}]},{"given":"R.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"CIISA, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, Lisboa, 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