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A total of 206 female dogs with spontaneous mammary tumors were enrolled in this study and circulating blood cells were genotyped. This specific SNP was associated with larger size (&gt;3 cm diameter) for malignant tumors ( P = .036), tumors with infiltrative\/invasive growth pattern ( P = .010), vascular invasion ( P = .006), and lymph node metastasis ( P = .004). Carriers of the variant allele had a shorter overall survival compared to the wild-type population with an overall survival of 18.7 months and 22.7 months, respectively ( P = .004). These findings suggest that SNP rs23932236 of canine PRL gene may be used as an indicator for the development of clinically aggressive forms of CMTs. <\/jats:p>","DOI":"10.1177\/03009858211022705","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T09:10:12Z","timestamp":1623661812000},"page":"1051-1057","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Single Nucleotide Polymorphism in Prolactin Gene Is Associated With Clinical Aggressiveness and Outcome of Canine Mammary Malignant Tumors"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-8454","authenticated-orcid":false,"given":"Ana","family":"Canadas-Sousa","sequence":"first","affiliation":[{"name":"Instituto Ci\u00eancias Biom\u00e9dicas Abel Salazar, ICBAS, UPorto, University of Porto, Porto, 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