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Vimentin immunoreactivity was assessed in neoplastic cells (in primary lesions, emboli, and metastases) and tumor-associated stroma (TAS) of canine GCs. Ki-67 PI was quantified in the neoplastic epithelial component. Vimentin immunolabeling in neoplastic cells was found in 30% of the primary lesions, in 82% of the neoplastic emboli, and in 50% of the metastases; in TAS, it was observed in all cases. A mean of 16% of the TAS was immunolabeled for vimentin. High vimentin immunolabeling in the TAS (&gt;16%) was detected in 40% of cases. The average value of Ki-67 PI was 50%, and 80% of the lesions had Ki-67 PI above 20%. Vimentin immunolabeling in neoplastic cells was more frequent in less-differentiated carcinomas (diffuse [29%] and indeterminate types [75%]) than well-differentiated carcinomas (intestinal type [0%], P = .049). No significant differences were observed in vimentin immunolabeling in the TAS or Ki-67 PI according to histological diagnosis, depth of invasion, presence of neoplastic emboli or metastases. However, vimentin immunolabeling in the TAS was positively correlated with Ki-67 PI ( r = .394, P = .031). Furthermore, a moderate negative correlation was observed between Ki-67 PI and survival time ( r = \u22120.540). Our results suggest that vimentin and Ki-67 PI have potential for providing prognostic information in cases of canine GCs.<\/jats:p>","DOI":"10.1177\/03009858221117858","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T07:51:30Z","timestamp":1660636290000},"page":"903-914","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Vimentin and Ki-67 immunolabeling in canine gastric carcinomas and their prognostic value"],"prefix":"10.1177","volume":"59","author":[{"given":"Ana R.","family":"Flores","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"},{"name":"University of Tr\u00e1s-os-Montes and Alto Douro, Vila Real, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences, 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Portugal"}]},{"given":"F\u00e1tima","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"},{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"}]},{"given":"Irina","family":"Amorim","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"},{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, 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