{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:07:33Z","timestamp":1777489653188,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Objectives: Migraine pathophysiology involves several pathways. Our aims were to explore a possible role of the brain-derived neurotrophic factor gene ( BDNF) in migraine susceptibility; to study, for the first time, the calcitonin gene-related peptide gene ( CGRP); and a possible interaction between the two.<\/jats:p>\n                  <jats:p>Methods: Using a case-control approach, four tagging single nucleotide polymorphisms (SNPs) (rs7124442, rs6265, rs11030107, and rs2049046) of BDNF and one tagging SNP\u2014rs1553005\u2014of CGRP were analyzed in 188 cases and 287 controls. A multivariable logistic regression was performed, adjusting for gender. Allelic and haplotypic frequencies were estimated. Interaction was assessed by a stepwise multivariable-logistic regression and confirmed by a multifactor dimensionality reduction analysis.<\/jats:p>\n                  <jats:p>Results: No significant main effects were found; however, a significant interaction was found between BDNF and CGRP, showing an increased risk for the AT-genotype of rs2049046 and the GC-genotype of rs1553005 (odds ratio\u2009=\u20091.88, 95% confidence interval: 1.20\u20132.93) for migraineurs.<\/jats:p>\n                  <jats:p>Conclusion: Our data support the hypothesis of an interaction between BDNF and CGRP in migraine susceptibility that should be further explored.<\/jats:p>","DOI":"10.1177\/0333102410368443","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T12:33:20Z","timestamp":1287491600000},"page":"1375-1382","source":"Crossref","is-referenced-by-count":40,"title":["BDNF and CGRP interaction: Implications in migraine susceptibility"],"prefix":"10.1177","volume":"30","author":[{"given":"Carolina","family":"Lemos","sequence":"first","affiliation":[{"name":"Universidade do Porto, Portugal."}]},{"given":"Denisa","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Portugal."}]},{"given":"Jos\u00e9","family":"Pereira-Monteiro","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Portugal."},{"name":"Centro Hospitalar do Porto-Hospital de Santo Ant\u00f3nio, Portugal."}]},{"given":"Jos\u00e9","family":"Barros","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto-Hospital de Santo Ant\u00f3nio, Portugal."}]},{"given":"Jorge","family":"Sequeiros","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Portugal."}]},{"given":"Isabel","family":"Alonso","sequence":"additional","affiliation":[{"name":"Universidade do Porto, Portugal."}]},{"given":"Alda","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade do Porto, 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