{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:23:41Z","timestamp":1759335821784,"version":"3.38.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Artif Organs"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p> The most serious problem related to the use of tunneled catheters in hemodialysis is bacteremia. The aim of this study was to detect hemodialysis catheter colonization and, establish a preemptive therapy based on a catheter antibiotic lock in order to prevent development of catheter-related bloodstream infections. During a 24-month period, all patients with tunneled catheters in our hemodialysis unit were evaluated by extracting a through-catheter leukocyte culture every 15 days. There were 28 episodes of catheter colonization occurring in 13 patients (2.2 colonization episodes per 1000 catheter patient-days). At the time of colonization, catheters had been in place for a mean of 562 days (range: 16 to 1475 days). Coagulase negative staphylococci (CNS) were the most common microorganisms to be isolated. A preemptive therapy consisting in teicoplanin locks (10 mg\/mL) for 21 days was able to eradicate catheter colonization in 89% of the cases when CNS were isolated. However, relapse of colonization occurred in 61.2% of these cases. The mean duration of catheter use was 239 days (range: 9 to 483 days) after treatment of a colonization episode. The incidence of catheter-related bloodstream infection in our population was 0.78 episodes per 1000 catheter patient-days (IC 95%: 0.374\u20131.434). This study shows the utility of intra-catheter leukocyte culture for early detection of hemodialysis catheter colonization. Moreover, it establishes that the eradication of biofilm-related CNS is possible without the removal of the catheter, thus enabling a longer catheter lifespan. (Int J Artif Organs 2008; 31: 820\u20136) <\/jats:p>","DOI":"10.1177\/039139880803100910","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T07:01:37Z","timestamp":1515740497000},"page":"820-826","source":"Crossref","is-referenced-by-count":8,"title":["Intra-Catheter Leukocyte Culture to Monitor Hemodialysis Catheter Colonization. a Prospective Study to Prevent Catheter-Related Bloodstream Infections"],"prefix":"10.1177","volume":"31","author":[{"given":"J.L.","family":"Del Pozo","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Clinical Microbiology, University Clinic of Navarra, Pamplona - Spain"},{"name":"Department of Microbiology, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"A.","family":"Aguinaga","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"N.","family":"Garcia-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"S.","family":"Hernaez","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"A.","family":"Serrera","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"M.","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"A.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"F.","family":"Guillen-Grima","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University Clinic of Navarra, Pamplona - Spain"}]},{"given":"J.","family":"Leiva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinic of Navarra, Pamplona - Spain"}]}],"member":"179","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"bibr1-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1159\/000046990"},{"key":"bibr2-039139880803100910","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-7-199804010-00020"},{"key":"bibr3-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.10.2288"},{"key":"bibr4-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.4.579"},{"key":"bibr5-039139880803100910","first-page":"34","volume":"51","author":"Dittmer I.D.","year":"1999","journal-title":"Clin Nephrol"},{"key":"bibr6-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1086\/502586"},{"key":"bibr7-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04070-2"},{"key":"bibr8-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1007\/BF01961854"},{"key":"bibr9-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1086\/320001"},{"key":"bibr10-039139880803100910","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-5-200003070-00009"},{"key":"bibr11-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00266-0"},{"key":"bibr12-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1177\/112972980200300106"},{"key":"bibr13-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2006.00131.x"},{"key":"bibr14-039139880803100910","first-page":"381","volume":"12","author":"Raad I.I.","year":"1994","journal-title":"Middle East J Anesthesiol"},{"key":"bibr15-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1086\/315369"},{"key":"bibr16-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000149838.47048.60"},{"key":"bibr17-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701741940"},{"key":"bibr18-039139880803100910","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-4-199708150-00003"},{"key":"bibr19-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.10.038"},{"key":"bibr20-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm847"},{"key":"bibr21-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1177\/0148607198022004242"},{"key":"bibr22-039139880803100910","doi-asserted-by":"publisher","DOI":"10.1159\/000046950"}],"container-title":["The International Journal of Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880803100910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/039139880803100910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T07:46:46Z","timestamp":1740815206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/039139880803100910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1177\/039139880803100910"],"URL":"https:\/\/doi.org\/10.1177\/039139880803100910","relation":{},"ISSN":["0391-3988","1724-6040"],"issn-type":[{"type":"print","value":"0391-3988"},{"type":"electronic","value":"1724-6040"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}