{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:16:57Z","timestamp":1777803417750,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>Acute secondary neurological deterioration after herpes simplex encephalitis has been reported. An immune-mediated process is thought to be responsible for some cases. The authors report the case of an infant who presented with fever, irritability, and orofacial involuntary movements, 15 days after herpes encephalitis onset. Polymerase chain reaction for herpes simplex virus was negative, and the magnetic resonance imaging revealed extensive white matter lesions. Chorea appeared only 11 days later. Raised immunoglobulin G index with oligoclonal bands and spreading of white matter lesions corroborated an immune-mediated etiology. An interferon production deficit was also detected. This case alerts that this form of \u2018\u2018relapse\u2019\u2019 appears earlier than previously reported. A high level of suspicion is needed in the presence of atypical neurological deterioration and early white matter lesions should be considered as a warning sign. This case is also relevant because it associates, for the first time, an immune-mediated \u2018\u2018relapse\u2019\u2019 to an interferon production deficit.<\/jats:p>","DOI":"10.1177\/0883073810382140","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T23:14:54Z","timestamp":1293146094000},"page":"369-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Early \u2018\u2018Relapse\u2019\u2019 After Herpetic Encephalitis: Extensive White Matter Lesions in an Infant With Interferon Production Deficit"],"prefix":"10.1177","volume":"26","author":[{"given":"Raquel","family":"Maia","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dona Estef\u00e2nia Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal,"}]},{"given":"Catarina","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Dona Estef\u00e2nia Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal"}]},{"given":"Ana","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Dona Estef\u00e2nia Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal"}]},{"given":"Jean Laurent","family":"Casanova","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA, Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris Descartes University, U980, Paris, France"}]},{"given":"Vanessa","family":"Sancho-Shimizu","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris Descartes University, U980, Paris, France"}]},{"given":"Maria Jo\u00e3o","family":"Brito","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Dona Estef\u00e2nia Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.07.007"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.07.007"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000073985.71759.7C"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199602)48:2<129::AID-JMV2>3.0.CO;2-B"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.10.1242"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1998.tb15431.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198403000-00016"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139522"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128346"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282f151d2"},{"key":"atypb11","author":"Abel L.","journal-title":"J Pediatr"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(99)00055-8"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220113"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073810382140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073810382140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:36:13Z","timestamp":1777494973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073810382140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,23]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1177\/0883073810382140"],"URL":"https:\/\/doi.org\/10.1177\/0883073810382140","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,23]]}}}