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In this work, organic\u2013inorganic hybrid membranes were prepared from tetraethoxysilane and a blend system composed of chitosan and soy protein. By introducing a small amount of siloxane bond into the chitosan\/soy protein system, the chitosan\/soy protein hybrid membranes were improved in terms of structure, topography and mechanical properties. It appears that the chitosan\/soy protein hybrid membranes were formed by discrete inorganic moieties entrapped in the chitosan\/soy protein blend, which improved the stability and mechanical performance assessed by the dynamic mechanical analysis as compared to chitosan\/soy protein membrane. Also, in vitro cell culture studies evidenced that the chitosan\/soy protein hybrid membranes are non-cytotoxic over a mouse fibroblast-like cell line. The hybrid membranes of silane-treated chitosan\/soy protein developed in this work have potential in biomedical applications, including tissue engineering.<\/jats:p>","DOI":"10.1177\/0883911513490361","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T22:36:04Z","timestamp":1371249364000},"page":"385-397","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Hybrid biodegradable membranes of silane-treated chitosan\/soy protein for biomedical applications"],"prefix":"10.1177","volume":"28","author":[{"given":"Simone S","family":"Silva","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group- Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Caldas das Taipas, 4806-909 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s- PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Joaquim M","family":"Oliveira","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group- Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Caldas das Taipas, 4806-909 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s- PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Johan","family":"Benesch","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group- Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Caldas das Taipas, 4806-909 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s- PT Government 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