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ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and\/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructure with 65%\u201385% porosity and pore sizes in the range of 100\u2013300 \u00b5m. The hydroxyapatite was found to be well distributed within the composite structures and had a positive effect in the viability and proliferation of osteoblast-like cells, in vitro. Our findings indicate that these ChHA matrices have potential applications in bone tissue engineering.<\/jats:p>","DOI":"10.1177\/0883911513501595","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T21:40:40Z","timestamp":1377639640000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Alternative methodology for chitin\u2013hydroxyapatite composites using ionic liquids and supercritical fluid technology"],"prefix":"10.1177","volume":"28","author":[{"given":"Simone S","family":"Silva","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group\u2014Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Ana Rita C","family":"Duarte","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group\u2014Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Joaquim M","family":"Oliveira","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group\u2014Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Jo\u00e3o F","family":"Mano","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group\u2014Biomaterials, Biodegradables and 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