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Poly(caprolactone) films with five different groove\u2013ridge sizes and three pattern depths were prepared by hot embossing technique. In general, the morphologies of osteoblast cell were not changed noticeably by the size changes in groove\u2013ridges with the same depth size. However, cell morphologies were changed significantly when pattern depths were increased from 1.35 to 4.95\u2009\u00b5m. Also, the cell morphology change between different groove\u2013ridges was significant when the pattern depth was small (1.35\u2009\u00b5m), and these effects were diminished or masked when the pattern depth was increased to 4.95\u2009\u00b5m. Linear regression analysis further clarifies that unit size changes in depth may affect cell length and orientation rates 2.4 and 4 times, respectively, in comparison to rates obtained from X\u2013Y planes. <\/jats:p>","DOI":"10.1177\/0883911515580354","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:01:37Z","timestamp":1429574497000},"page":"555-567","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Depth (Z-axis) control of cell morphologies on micropatterned surfaces"],"prefix":"10.1177","volume":"30","author":[{"given":"Erkan T","family":"Baran","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group\u2014Biomaterials, Biodegradable and Biomimetic, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s PT Government Associated 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