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The effect of filler composition and concentration (0, 30, 40 and 50\u2009wt%) on the curing parameters, residual monomer, water uptake, weight loss, bioactivity, mechanical properties (bending and compression) and osteoblast cytocompatibility was evaluated. The addition of bioactive glass filler significantly improved the cements curing parameters and the mechanical properties. The most relevant results were obtained for the lower filler concentration (30\u2009wt%) a maximum flexural strength of 40.4\u2009MPa for MB3 and a maximum compressive strength of 95.7\u2009MPa for MSi3. In\u00a0vitro bioactivity in acellular media was enhanced by the higher glass contents in the cements. Regarding the biological assessment, the incorporation of the silicate glass significantly improved osteoblast cytocompatibility, whereas the presence of the borate glass resulted in a poor cell response. Nevertheless it was shown that the surviving cells on the MB surface were in a more differentiated stage compared to those growing over non-filled poly(methyl methacrylate). Results suggest that the developed formulations offer a high range of properties that might be interesting for their use as self-curing cements.<\/jats:p>","DOI":"10.1177\/0885328212457097","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:36:34Z","timestamp":1345682194000},"page":"498-513","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Properties and osteoblast cytocompatibility of self-curing acrylic cements modified by glass fillers"],"prefix":"10.1177","volume":"28","author":[{"given":"PP","family":"Lopes","sequence":"first","affiliation":[{"name":"Centre for Research in Ceramic and Composite Materials CICECO and Department of Ceramics and Glass Engineering, University of Aveiro, Campus Universit\u00e1rio de Santiago, Aveiro, Portugal"}]},{"given":"MP","family":"Garcia","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Cellular Biocompatibility, Faculty of Dental Medicine, University of Porto, Rua Dr Manuel Pereira da Silva, Porto, Portugal"}]},{"given":"MH","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Cellular Biocompatibility, Faculty of Dental Medicine, University of Porto, Rua Dr Manuel Pereira da Silva, Porto, Portugal"}]},{"given":"MHV","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centre for Research in Ceramic and Composite Materials CICECO and Department of Ceramics and Glass Engineering, University of Aveiro, Campus Universit\u00e1rio de Santiago, Aveiro, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2012,8,22]]},"reference":[{"key":"bibr1-0885328212457097","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199722)38:2<155::AID-JBM10>3.0.CO;2-C"},{"key":"bibr2-0885328212457097","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00554-4"},{"key":"bibr3-0885328212457097","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200200002-00002"},{"key":"bibr4-0885328212457097","unstructured":"National joint registry for England and Wales: 7\n                      th\n                      Annual Report 2009. 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