{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:02:03Z","timestamp":1777788123923,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    Nanohydroxyapatite (nanoHA), due to its chemical properties, has appeared as an exceptionally promising bioceramic to be used as bone regeneration material. Staphylococcus epidermidis have emerged as major nosocomial pathogens associated with infections of implanted medical devices. In this work, the purpose was to study the influence of the nanoHA surface characteristics on S. epidermidis RP62A biofilm formation. Therefore, two different initial inoculum concentrations (C\n                    <jats:sub>i<\/jats:sub>\n                    ) were used in order to check if these would affect the biofilm formed on the nanoHA surfaces. Biofilm formation was followed by the enumeration of cultivable cells and by scanning electron microscopy. Surface topography, contact angle, total surface area and porosimetry of the biomaterials were studied and correlated with the biofilm data. The surface of nanoHA sintered at 830\u2103 (nanoHA830) showed to be more resistant to S. epidermidis attachment and accumulation than that of nanoHA sintered at 1000\u2103 (nanoHA1000). The biofilm formed on nanoHA830 presented differences in terms of structure, surface coverage and EPS production when compared to the one formed on nanoHA1000 surface. It was observed that topography and surface area of nanoHA surfaces had influence on the bacterial attachment and accumulation. C\n                    <jats:sub>i<\/jats:sub>\n                    influenced bacteria attachment and accumulation on nanoHA surfaces over time. The choice of the initial inoculum concentration was relevant proving to have an effect on the extent of adherence thus being a critical point for human health if these materials are used in implantable devices. This study showed that the initial inoculum concentration and surface material properties determine the rate of microbial attachment to substrata and consequently are related to biofilm-associated infections in biomaterials.\n                  <\/jats:p>","DOI":"10.1177\/0885328213507300","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T23:27:21Z","timestamp":1381534041000},"page":"1325-1335","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Influence of nanohydroxyapatite surface properties on\n                    <i>Staphylococcus epidermidis<\/i>\n                    biofilm formation"],"prefix":"10.1177","volume":"28","author":[{"given":"J","family":"Barros","sequence":"first","affiliation":[{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Porto, Portugal"},{"name":"Departamento de Engenharia Metal\u00fargica e Materiais, FEUP \u2013 Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"},{"name":"LEPAE \u2013 Laborat\u00f3rio de Engenharia dos Processos, Ambiente e Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"}]},{"given":"L","family":"Grenho","sequence":"additional","affiliation":[{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Porto, Portugal"},{"name":"Departamento de Engenharia Metal\u00fargica e Materiais, FEUP \u2013 Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"}]},{"given":"CM","family":"Manuel","sequence":"additional","affiliation":[{"name":"LEPAE \u2013 Laborat\u00f3rio de Engenharia dos Processos, Ambiente e Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"},{"name":"ULP \u2013 Universidade Lus\u00f3fona do Porto, Porto, Portugal"}]},{"given":"C","family":"Ferreira","sequence":"additional","affiliation":[{"name":"LEPAE \u2013 Laborat\u00f3rio de Engenharia dos Processos, Ambiente e Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"}]},{"given":"L","family":"Melo","sequence":"additional","affiliation":[{"name":"LEPAE \u2013 Laborat\u00f3rio de Engenharia dos Processos, Ambiente e Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"}]},{"given":"OC","family":"Nunes","sequence":"additional","affiliation":[{"name":"LEPAE \u2013 Laborat\u00f3rio de Engenharia dos Processos, Ambiente e Energia, Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"}]},{"given":"FJ","family":"Monteiro","sequence":"additional","affiliation":[{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Porto, Portugal"},{"name":"Departamento de Engenharia Metal\u00fargica e Materiais, FEUP \u2013 Faculdade de Engenharia \u2013 Universidade do Porto, Porto, Portugal"}]},{"given":"MP","family":"Ferraz","sequence":"additional","affiliation":[{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Porto, Portugal"},{"name":"CEBIMED \u2013 Centro de Estudos em Biomedicina, Universidade Fernando Pessoa, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"bibr1-0885328213507300","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr10215j"},{"key":"bibr2-0885328213507300","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00174-5"},{"key":"bibr3-0885328213507300","first-page":"74","volume":"2","author":"Ferraz MP","year":"2004","journal-title":"J Appl Biomater 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