{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:02:16Z","timestamp":1777788136962,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>The search for apatitic calcium phosphate coatings to improve implants osteointegration is, nowadays, preferentially focused in the obtaining of compositions closer to that of the inorganic phase of bone. Silicon and strontium are both present in trace concentrations in natural bone and have been demonstrated, by separate, to significantly improve osteoblastic response on calcium phosphate bioceramics. This work aims the controlled and simultaneous multi-doping of carbonated calcium phosphate coatings with both elements, Si and Sr, by pulsed laser deposition technique and the biological response of human mesenchymal stem cells to them. A complete physicochemical characterization has been also performed to analyze the coatings and significant positive effect was obtained at the osteogenic differentiation of cells, confirming the enormous potential of this multi-doping coating approach.<\/jats:p>","DOI":"10.1177\/0885328213510056","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T21:00:29Z","timestamp":1382734829000},"page":"1397-1407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings"],"prefix":"10.1177","volume":"28","author":[{"given":"Cosme","family":"Rodr\u00edguez-Valencia","sequence":"first","affiliation":[{"name":"New Materials Group, Applied Physics Dpt., Institute of Biomedical Research of Vigo (IBIV), University of Vigo, Spain"}]},{"given":"Iago","family":"Pereiro","sequence":"additional","affiliation":[{"name":"New Materials Group, Applied Physics Dpt., Institute of Biomedical Research of Vigo (IBIV), University of Vigo, Spain"}]},{"given":"Rogelio P","family":"Pirraco","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group \u2013 Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s Laborat\u00f3rio Associado, PT Government Associated Laboratory, Braga, Portugal"}]},{"given":"Miriam","family":"L\u00f3pez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"New Materials Group, Applied Physics Dpt., Institute of Biomedical Research of Vigo (IBIV), University of Vigo, Spain"}]},{"given":"Julia","family":"Serra","sequence":"additional","affiliation":[{"name":"New Materials Group, Applied Physics Dpt., Institute of Biomedical Research of Vigo (IBIV), University of Vigo, Spain"}]},{"given":"P\u00edo","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"New Materials Group, Applied Physics Dpt., Institute of Biomedical Research of Vigo (IBIV), University of Vigo, Spain"}]},{"given":"Alexandra P","family":"Marques","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group \u2013 Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s Laborat\u00f3rio Associado, PT Government Associated Laboratory, Braga, Portugal"}]},{"given":"Rui L","family":"Reis","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group \u2013 Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s Laborat\u00f3rio Associado, PT Government Associated Laboratory, Braga, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"bibr1-0885328213510056","first-page":"54","volume-title":"Bioceramics: material characteristics versus in\u00a0vivo behavior","author":"Hench LL","year":"1998"},{"key":"bibr2-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(03)01128-3"},{"key":"bibr3-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00146-4"},{"key":"bibr4-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(94)90264-X"},{"key":"bibr5-0885328213510056","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2011.590762"},{"key":"bibr6-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30932"},{"key":"bibr7-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.01.050"},{"key":"bibr8-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018549720873"},{"key":"bibr9-0885328213510056","doi-asserted-by":"publisher","DOI":"10.3989\/revmetalm.1998.v34.i2.666"},{"key":"bibr10-0885328213510056","doi-asserted-by":"publisher","DOI":"10.3390\/ma3073994"},{"key":"bibr11-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4332(02)00002-8"},{"key":"bibr12-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018549720873"},{"key":"bibr13-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77718-4_5"},{"key":"bibr14-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2005.03.111"},{"key":"bibr15-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30556"},{"key":"bibr16-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/110.5.1046"},{"key":"bibr17-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/27.5.515"},{"key":"bibr18-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D"},{"key":"bibr19-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-3010.2005.00507.x"},{"key":"bibr20-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1042\/bj0670104"},{"key":"bibr21-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)56336-5"},{"key":"bibr22-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.04.026"},{"key":"bibr23-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(96)00080-4"},{"key":"bibr24-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.12.7190"},{"key":"bibr25-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080512"},{"key":"bibr26-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2007.02.116"},{"key":"bibr27-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2012.04.063"},{"key":"bibr28-0885328213510056","first-page":"3","volume":"449","author":"Wolfe M","year":"2008","journal-title":"Methods Mol Biol"},{"key":"bibr29-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3658-0"},{"key":"bibr30-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10579"},{"key":"bibr31-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1002\/sia.1249"},{"key":"bibr32-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2007.09.041"},{"key":"bibr33-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.04.010"},{"key":"bibr34-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/18\/24\/245101"},{"key":"bibr35-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.04.018"},{"key":"bibr36-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.12.041"},{"key":"bibr37-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-005-4720-9"},{"key":"bibr38-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.05.005"},{"key":"bibr39-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2006.10.012"},{"key":"bibr40-0885328213510056","first-page":"278","volume":"20","author":"Chen D","year":"2001","journal-title":"Chin J Biomed Eng"},{"key":"bibr41-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.05.003"},{"key":"bibr42-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.08.031"},{"key":"bibr43-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2006.05.016"},{"key":"bibr44-0885328213510056","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-006-0432-z"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328213510056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885328213510056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328213510056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:52:56Z","timestamp":1777492376000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885328213510056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,25]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/0885328213510056"],"URL":"https:\/\/doi.org\/10.1177\/0885328213510056","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,25]]}}}