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These scaffolds were in\u00a0vitro seeded and cultured with human bone marrow stromal cells in osteogenic conditions, revealing that higher percentage of chitosan showed enhanced cell viability over time, adhesion, proliferation, and osteogenic differentiation. Scaffolds were also implanted in cranial defects and iliac submuscular region in Wistar rats, and the results evidenced that chitosan-containing scaffolds displayed mild inflammatory response and good integration with surrounding tissues, showed by connective tissue colonization and the presence of new blood vessels. Scaffolds without chitosan-evidenced necrotic tissue in scaffolds\u2019 interior, proving that chitosan exerts a positive effect over cell behavior and displays a milder host inflammatory response in\u00a0vivo.<\/jats:p>","DOI":"10.1177\/0885328213512385","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T22:39:18Z","timestamp":1384900758000},"page":"1430-1442","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of scaffold composition over in\u00a0vitro osteogenic differentiation of hBMSCs and in\u00a0vivo inflammatory response"],"prefix":"10.1177","volume":"28","author":[{"given":"Ana R","family":"Costa-Pinto","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group \u2013 Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, 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