{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:06:28Z","timestamp":1768565188285,"version":"3.49.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/97995\/2013"],"award-info":[{"award-number":["SFRH\/BD\/97995\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["400398\/2014-1"],"award-info":[{"award-number":["400398\/2014-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p> Copper nanoparticles stabilized with cashew (CG-CuNPs) were synthesized by reduction reaction using ascorbic acid and sodium borohydride, using the cashew gum (CG) as a natural polymer stabilizer. Dynamic light scattering, atomic force microscopy, Fourier-transform infrared spectroscopy, UV-Vis spectrophotometry, and x-ray diffraction were used to characterize the nanoparticles (CG-CuNPs), and copper was quantified by electrochemical measurement. The UV-vis spectra of the CG-CuNPs confirmed the formation of nanoparticles by appearance of a surface plasmon band at 580 nm after 24 h of reaction. The Fourier-transform infrared spectrum of CG-CuNPs showed the peak at 1704 cm<jats:sup>\u22121<\/jats:sup> from cashew gum, confirming the presence of the gum in the nanoparticles. The average size of CG-CuNPs by dynamic light scattering and atomic force microscopy was around 10 nm, indicating small, approximately spherical particles. Antimicrobial assays showed that CG-CuNPs had activity against Staphylococcus aureus ATCC 29213 with a minimal inhibitory concentration of 0.64 mM. The cytotoxicity assay on BALB\/c murine macrophages showed lower cytotoxic effects for CG-CuNPs than CuSO<jats:sub>4<\/jats:sub>\u00b75H<jats:sub>2<\/jats:sub>O. Viability cell assays for CG-CuNPs at (0.250 mM) inhibited by 70% the growth of 4T1 LUC (4T1 mouse mammary tumor cell line) and NIH 3T3 cells (murine fibroblast cells) over a 24-h period. Therefore, CG-CuNPs can be used as an antimicrobial agent with lower cytotoxic effects than the CuSO<jats:sub>4<\/jats:sub>\u00b75H<jats:sub>2<\/jats:sub>O precursor. <\/jats:p>","DOI":"10.1177\/0885328219845964","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T14:39:18Z","timestamp":1556721558000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Copper nanoparticles stabilized with cashew gum: Antimicrobial activity and cytotoxicity against 4T1 mouse mammary tumor cell line"],"prefix":"10.1177","volume":"34","author":[{"given":"Adriany","family":"Amorim","sequence":"first","affiliation":[{"name":"Centre for Biodiversity Research and Biotechnology, Biotec, Universidade Federal do Piaui, Parna\u00edba 64202020, PI, Brazil"}]},{"given":"Ana Carolina","family":"Mafud","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Physical Institute, University of S\u00e3o Paulo, USP, S\u00e3o Carlos 13566590, SP, Brazil"}]},{"given":"Silvania","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Centre for Biodiversity Research and Biotechnology, Biotec, Universidade Federal do Piaui, Parna\u00edba 64202020, PI, Brazil"}]},{"given":"Joilson Ramos-","family":"Jesus","sequence":"additional","affiliation":[{"name":"Centre for Biodiversity Research and Biotechnology, Biotec, Universidade Federal do Piaui, Parna\u00edba 64202020, PI, Brazil"}]},{"given":"Alyne Rodrigues de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Centre for Biodiversity Research and Biotechnology, Biotec, Universidade Federal do Piaui, Parna\u00edba 64202020, PI, Brazil"}]},{"given":"Alexandra","family":"Pl\u00e1cido","sequence":"additional","affiliation":[{"name":"Glial Cell Biology Lab, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto 4200135, 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