{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:19:16Z","timestamp":1776899956056,"version":"3.51.2"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Programa Operacional Competitividade e Internacionaliza\u00e7\u00e3o - POCI","award":["POCI-01-0145-FEDER-029232"],"award-info":[{"award-number":["POCI-01-0145-FEDER-029232"]}]},{"name":"LAETA","award":["UIDB\/50022\/2020"],"award-info":[{"award-number":["UIDB\/50022\/2020"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Proc Inst Mech Eng H"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p> Synthetic implants were used for repair of anterior compartment prolapses, which can be caused by direct trauma resulting in damaged pelvic structures. The mechanical properties of these implants may cause complications, namely erosion of the mesh through the vagina. In this study, we evaluated, by modeling, the behavior of implants, during Valsalva maneuver, used to replace damaged uterosacral ligaments (USLs), mimicking a sacrocolpopexy repair. For this purpose, two synthetic implants (A, for prolapse repair and B, for Hernia repair) were uniaxially tested, and the mechanical properties obtained were incorporated in the computational models of the implants. The computational model for the implant was incorporated into the model of the female pelvic cavity, in order to mimic the USLs after its total rupture and with 90% and 50% impairment. The total rupture and impairments of the USLs, caused a variation of the supero-inferior displacement and displacement magnitude of the vagina, with higher values for the total rupture. With total rupture of the USLs, when compared to healthy USLs, supero-inferior displacement and displacement magnitude of the vagina increased by 4.98\u2009mm (7.69\u2009mm vs 12.67\u2009mm) and 6.62\u2009mm (9.38\u2009mm vs 16.00\u2009mm), respectively. After implantation (A and B) a reduction of the supero-inferior displacements of the anterior vaginal wall occurred, to values found in the case of the model without any impairment or rupture of the ligaments. The simulation was able to mimic the biomechanical response of the USLs, in response to different implants stiffnesses, which can be used in the development of novel meshes. <\/jats:p>","DOI":"10.1177\/09544119221074567","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T10:39:53Z","timestamp":1643366393000},"page":"573-582","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Simulation of vaginal uterosacral ligament suspension damage, mimicking a mesh-augmented apical prolapse repair"],"prefix":"10.1177","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-4969","authenticated-orcid":false,"given":"Maria Elisabete Teixeira da","family":"Silva","sequence":"first","affiliation":[{"name":"LAETA, INEGI, Faculty of Engineering, University of Porto, Porto, Portugal"}]},{"given":"Jorge Nuno Machado","family":"Bessa","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, University of Porto, Porto, Portugal"}]},{"given":"Rita","family":"Rynkevic","sequence":"additional","affiliation":[{"name":"LAETA, INEGI, Faculty of Engineering, University of Porto, Porto, Portugal"}]},{"given":"Marco Paulo Lages","family":"Parente","sequence":"additional","affiliation":[{"name":"LAETA, INEGI, Faculty of Engineering, University of Porto, Porto, Portugal"}]},{"given":"Maria Teresa da Quinta e Costa Mascarenhas","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHSJ-EPE\/Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Renato Manuel","family":"Natal Jorge","sequence":"additional","affiliation":[{"name":"LAETA, INEGI, Faculty of Engineering, University of Porto, Porto, Portugal"}]},{"given":"Ant\u00f3nio Augusto","family":"Fernandes","sequence":"additional","affiliation":[{"name":"LAETA, INEGI, Faculty of Engineering, University of Porto, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"bibr1-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.01.027"},{"key":"bibr2-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.02.022"},{"key":"bibr3-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000227786.69257.a8"},{"key":"bibr4-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-015-2695-8"},{"key":"bibr5-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-018-03862-0"},{"key":"bibr6-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-019-0741-2"},{"key":"bibr7-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.046"},{"key":"bibr8-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0b013e318254f09c"},{"key":"bibr9-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.015"},{"issue":"1","key":"bibr10-09544119221074567","first-page":"5","volume":"21","author":"Haylen BT","year":"2010","journal-title":"Neurourol Urodyn"},{"key":"bibr11-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-012-0136-9"},{"key":"bibr12-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00058-6"},{"key":"bibr13-09544119221074567","unstructured":"FDA. Urogynecologic surgical mesh implants, https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-takes-action-protect-womens-health-orders-manufacturers-surgical-mesh-intended-transvaginal (2021, accessed 16 September 2021)."},{"key":"bibr14-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.03.013"},{"key":"bibr15-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1177\/0954411916630571"},{"key":"bibr16-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1401-9"},{"key":"bibr17-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2017.1304542"},{"key":"bibr18-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1142\/S0219519417500907"},{"key":"bibr19-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2018.01.033"},{"key":"bibr20-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2008.06.037"},{"key":"bibr21-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.02.032"},{"key":"bibr22-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.02.033"},{"key":"bibr23-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1115\/1.4036606"},{"key":"bibr24-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1080\/21681163.2019.1670095"},{"key":"bibr25-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-018-3706-3"},{"key":"bibr26-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1115\/1.4041524"},{"key":"bibr27-09544119221074567","volume-title":"In vivo models and in silico simulations of mesh augmented prolapse","author":"Rynkevic R","year":"2019"},{"key":"bibr28-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9518076"},{"key":"bibr29-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.11.045"},{"key":"bibr30-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1148\/rg.284075139"},{"key":"bibr31-09544119221074567","volume-title":"Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants","author":"Bhattarai A","year":"2018"},{"key":"bibr32-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1305.2006.00257.x"},{"key":"bibr33-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.11.010"},{"key":"bibr34-09544119221074567","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.150088"},{"key":"bibr35-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12085"},{"key":"bibr36-09544119221074567","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2011.03.art1"},{"key":"bibr37-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1115\/1.4039058"},{"key":"bibr38-09544119221074567","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-7825(97)00162-X"}],"container-title":["Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09544119221074567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09544119221074567","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09544119221074567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T19:44:29Z","timestamp":1740771869000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09544119221074567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/09544119221074567"],"URL":"https:\/\/doi.org\/10.1177\/09544119221074567","relation":{},"ISSN":["0954-4119","2041-3033"],"issn-type":[{"value":"0954-4119","type":"print"},{"value":"2041-3033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]}}}