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We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.<\/jats:p>","DOI":"10.1177\/09564624241296583","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T06:35:22Z","timestamp":1730442922000},"page":"161-163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-829X","authenticated-orcid":false,"given":"Francisca Bartilotti","family":"Matos","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Dara","family":"Mbanze","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Perp\u00e9tua","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Servi\u00e7o de Patologia Cl\u00ednica, Unidade Local de Sa\u00fade Lisboa Ocidental, Hospital Egas Moniz Lisbon, Portugal"},{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Caparica Almada, Portugal"}]},{"given":"Crist\u00f3v\u00e3o","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Daniel","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Sofia","family":"Nunes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Carlos","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Joana","family":"Fragoso","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Tiago","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"Lu\u00eds","family":"Malheiro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infeciosas, Unidade Local de Sa\u00fade Gaia\/Espinho, Vila Nova de Gaia, Portugal"},{"name":"Faculty of Medicine of University of Porto Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"bibr1-09564624241296583","unstructured":"World Health Organization. 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