{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:19:55Z","timestamp":1777666795875,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>Amitriptyline is a tricyclic antidepressant widely used in the treatment of depression. Antidepressant drugs are among the most commonly encountered causes of self-poisoning, as illustrated by several published cases in the literature. This investigation reports a case of massive amitriptyline intoxication, involving a 44-year old female found dead in bed. The presence of this tricyclic antidepressant was revealed by a routine screening procedure. The concentration was calculated by gas chromatography\/ electron ionization-mass spectrometry in the selected ion monitoring mode after solid-phase extraction using proadifen as internal standard and was in the post-mortem whole blood sample 85.9 \u03bcg\/mL. This value was much higher than the reported toxic values ever found in the literature, and may therefore have caused the victim's death. Nortriptyline was also detected in the toxic concentration range, as well as therapeutic levels of diazepam and nor-diazepam. Taking into account both the available circumstantial information and toxicological results, it is very likely that death was caused by self-poisoning. Human &amp; Experimental Toxicology (2007) 26, 667\u2014670<\/jats:p>","DOI":"10.1177\/0960327107076813","type":"journal-article","created":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T10:48:28Z","timestamp":1190285308000},"page":"667-670","source":"Crossref","is-referenced-by-count":8,"title":["Massive intoxication involving unusual high concentration of amitriptyline"],"prefix":"10.1177","volume":"26","author":[{"given":"Cl\u00e1udia","family":"Margalho","sequence":"first","affiliation":[{"name":"Instituto Nacional de Medicina Legal, Delega\u00e7\u00e3o de Coimbra, Largo da S\u00e9 Nova, 3000-213 Coimbra, Portugal,"}]},{"given":"M\u00e1rio","family":"Barroso","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Medicina Legal, Delega\u00e7\u00e3o de Coimbra, Largo da S\u00e9 Nova, 3000-213 Coimbra, Portugal"}]},{"given":"Eugenia","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Legal, Servicio de Toxicolog\u00eda Forense, San Francisco s\/n, 15786 Santiago de Compostela, Spain"}]},{"given":"Paula","family":"Monsanto","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Medicina Legal, Delega\u00e7\u00e3o de Coimbra, Largo da S\u00e9 Nova, 3000-213 Coimbra, Portugal"}]},{"given":"Duarte Nuno","family":"Vieira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Medicina Legal, Delega\u00e7\u00e3o de Coimbra, Largo da S\u00e9 Nova, 3000-213 Coimbra, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2007,8,1]]},"reference":[{"key":"atypb1","unstructured":"Baselt RC Disposition of toxic drugs and chemicals in man, 7th ed. Biomedical Publications, Foster City, 2004: 55\u201459."},{"key":"atypb2","unstructured":"Baldessarini RJ Drugs and the treatment of psychiatric disorders. In Hardman JG, and Limbird LE Editors-in-chief. Goodman & Gillman's the pharmacological basis of therapeutics, 9th ed. McGraw-Hill, New York, 1996: 431\u201459."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1097\/01.paf.0000154111.69255.ab"},{"key":"atypb4","volume-title":"Mosby's drug consult [document online] [cited July 2005]"},{"key":"atypb5","unstructured":"del R\u00edo J. F\u00e1rmacos antidepresivos y antiman\u00edacos. In Fl\u00f3rez J ed. Farmacolog\u00eda humana 3th ed. Masson, S.A. Barcelona, 1997: 549\u201463."},{"key":"atypb6","volume-title":"Therapeutic and toxic drug concentrations list. TIAFT [document online] [cited 8th July 2005]","author":"Uges D."},{"key":"atypb7","unstructured":"Reppeto M R., Reppeto M. 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