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Microsatellite instability (MSI) is regarded as one of the phenotypes of defective DNA MMR and, consequently, as a marker of high risk for cancer. The purpose of this work is to determine whether cadmium, in the form of cadmium chloride (CdCl<jats:sub>2<\/jats:sub>), may induce microsatellite mutations in murine testes. For this study, 2-month-old male ICR-CD1 mice were treated by a single subcutaneous injection of 1, 2 and 3 mg CdCl<jats:sub>2<\/jats:sub>\/kg body weight and killed after 35 days. A panel of six microsatellite markers, previously reported as being the most sensitive in detecting MSI in murine tumours, was used in this study. The results show that CdCl<jats:sub>2<\/jats:sub> in the doses of 2 and 3 mg\/kg induced a decrease in the testis weight and severe histopathologic changes with complete disorganization of testicular structure and evidences of severe necrosis. In addition, the animals exposed to the lowest CdCl<jats:sub>2<\/jats:sub> dose presented MSI in the testis. The results indicate the existence of MSI in at least two nuclear loci suggesting putative genotoxic effects induced by cadmium. <\/jats:p>","DOI":"10.1177\/0960327112445937","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T04:39:50Z","timestamp":1339735190000},"page":"1228-1236","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Cadmium-induced genetic instability in mice testis"],"prefix":"10.1177","volume":"31","author":[{"given":"Helena","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Biology, CICECO, University of Aveiro, Aveiro, Portugal"}]},{"given":"Tina","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Biology, CESAM, University of Aveiro, Aveiro, Portugal"}]},{"given":"T\u00e2nia","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Biology, CESAM, University of Aveiro, 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