{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:00:15Z","timestamp":1777928415621,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>\n                    The safety and efficacy of mycophenolate mofetil (MMF) were evaluated in adolescent patients with systemic lupus erythematosus and active or active\/chronic class III\u2013V lupus nephritis. During the 24-week induction phase, patients were randomized to oral MMF (target dose 3.0\u2009g\/day) or intravenous cyclophosphamide (IVC) (0.5\u20131.0\u2009g\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/month), plus prednisone. Response was defined as a decrease in 24-hour urine protein:creatinine ratio (P:Cr) to &lt;3 in patients with baseline nephrotic range proteinuria, or by \u226550% if subnephrotic baseline proteinuria, and stabilization (\u00b125%) or improvement in serum creatinine. In the 36-month maintenance phase, induction therapy responders were randomized 1:1 to MMF (1.0\u2009g twice daily) or oral azathioprine (AZA) (2\u2009mg\/kg\/day), plus prednisone. In the induction phase, 10 patients received MMF and 14 received IVC; 15 (62.5%) achieved treatment response (MMF, 7 (70%); IVC, 8\/15 (57.1%); p\u2009=\u20090.53, odds ratio (95% confidence interval) 2.0 (0.2, 15.5)). There was a non-statistically significant difference in maintenance of response to MMF (7\/8; 87.5%) versus AZA (3\/8; 37.5%). Seven patients withdrew (MMF, 2; AZA, 5). During both phases, rates of serious adverse events were similar in both arms. During both phases treatment response with MMF was as effective as the comparator.\n                  <\/jats:p>","DOI":"10.1177\/0961203312458466","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T23:51:41Z","timestamp":1345852301000},"page":"1433-1443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Efficacy of mycophenolate mofetil in adolescent patients with lupus nephritis: evidence from a two-phase, prospective randomized trial"],"prefix":"10.1177","volume":"21","author":[{"given":"R","family":"Sundel","sequence":"first","affiliation":[{"name":"Boston Children\u2019s Hospital, and Department of Pediatrics, Harvard Medical School, USA"}]},{"given":"N","family":"Solomons","sequence":"additional","affiliation":[{"name":"Clinical Department, Vifor Pharma (formerly Aspreva Pharmaceuticals), Canada"}]},{"given":"L","family":"Lisk","sequence":"additional","affiliation":[{"name":"Vifor Pharma \u2013 Aspreva, UK"}]},{"name":"Aspreva Lupus Management Study (ALMS) Group","sequence":"additional","affiliation":[]}],"member":"179","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"bibr1-0961203312458466","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00490109"},{"key":"bibr2-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2065oa"},{"key":"bibr3-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360310"},{"key":"bibr4-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2009.12.012"},{"key":"bibr5-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199809000-00014"},{"key":"bibr6-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310387179"},{"key":"bibr7-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008101028"},{"key":"bibr8-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014460"},{"key":"bibr9-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307084712"},{"key":"bibr10-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198603063141004"},{"key":"bibr11-0961203312458466","first-page":"318","volume":"55","author":"Fu YF","year":"2001","journal-title":"Clin Nephrol"},{"key":"bibr12-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V104833"},{"key":"bibr13-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678840927"},{"key":"bibr14-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1291-x"},{"key":"bibr15-0961203312458466","first-page":"2103","volume":"28","author":"Buratti S","year":"2001","journal-title":"J Rheumatol"},{"key":"bibr16-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1234130"},{"key":"bibr17-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308094999"},{"key":"bibr18-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0800-7"},{"key":"bibr19-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1016\/j.nephro.2010.07.001"},{"key":"bibr20-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.178608"},{"key":"bibr21-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2007.07.006"},{"key":"bibr22-0961203312458466","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep346"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312458466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203312458466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312458466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:12:35Z","timestamp":1777677155000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203312458466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,24]]},"references-count":22,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1177\/0961203312458466"],"URL":"https:\/\/doi.org\/10.1177\/0961203312458466","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,24]]}}}