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Methods: A cross-sectional analysis of SLE patients from the Portuguese Lupus register Reuma.pt\/SLE in whom damage assessment using the SLICC\/ACR-Disability Index (SDI) was available was performed. Predictor factors for damage, defined as SDI\u2009\u2265\u20091, were determined by logistic regression analyses. A sub-analysis of patients with severe damage (SDI\u2009\u2265\u20093) was also performed. Results: In total, 976 patients were included. SDI was \u22651 in 365 patients, of whom 89 had severe damage. Musculoskeletal (24.4%), neuropsychiatric (24.1%) and ocular (17.2%) domains were the most commonly affected. Older age, longer disease duration, renal involvement, presence of antiphospholipid antibodies and current therapy with steroids were independently associated with SDI\u2009\u2265\u20091. The subpopulation with severe damage had, in addition, a greater interval between the first manifestation attributable to SLE and the clinical diagnosis as well as and more frequently early retirement due to SLE. Conclusions: This large lupus cohort confirmed that demographic and clinical characteristics as well as medication are independently associated with damage. Additionally, premature retirement occurs more often in patients with SDI\u2009\u2265\u20093. Diagnosis delay might contribute to damage accrual.<\/jats:p>","DOI":"10.1177\/0961203314555172","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T20:32:54Z","timestamp":1413405174000},"page":"256-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Characterization of damage in Portuguese lupus patients: analysis of a national lupus registry"],"prefix":"10.1177","volume":"24","author":[{"given":"M J","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Hospital de Santa Maria, Lisboa, Portugal"},{"name":"Rheumatology Research Unit, Instituto de Medicina Molecular, Lisboa, Portugal"}]},{"given":"S","family":"Sousa","sequence":"additional","affiliation":[{"name":"Hospital Garcia de Orta, Almada, Portugal"}]},{"given":"L S","family":"In\u00eas","sequence":"additional","affiliation":[{"name":"Hospitais da Universidade de Coimbra, Coimbra, 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