{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T03:20:25Z","timestamp":1773544825060,"version":"3.50.1"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T00:00:00Z","timestamp":1471651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS\/PT) might contribute to a better identification of antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted to ascertain the value of aPS\/PT for APS diagnosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> In the initial study (eight centres, seven countries), clinical\/laboratory data were retrospectively collected. Serum\/plasma samples were tested for IgG aPS\/PT at Inova Diagnostics (Inova) using two ELISA kits. A replication study (five centres, five countries) was carried out afterwards. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In the initial study ( n\u2009=\u2009247), a moderate agreement between the IgG aPS\/PT Inova and MBL ELISA kits was observed ( k\u2009=\u20090.598). IgG aPS\/PT were more prevalent in APS patients (51%) than in those without (9%), OR 10.8, 95% CI (4.0\u201329.3), p\u2009&lt;\u20090.0001. Sensitivity, specificity, positive (LR+) and negative (LR\u2013) likelihood ratio of IgG aPS\/PT for APS diagnosis were 51%, 91%, 5.9 and 0.5, respectively. In the replication study ( n\u2009=\u2009214), a moderate\/substantial agreement between the IgG aPS\/PT results obtained with both ELISA kits was observed ( k\u2009=\u20090.630). IgG aPS\/PT were more prevalent in APS patients (47%) than in those without (12%), OR 6.4, 95% CI (2.6\u201316), p\u2009&lt;\u20090.0001. Sensitivity, specificity, LR\u2009+\u2009and LR\u2013 for APS diagnosis were 47%, 88%, 3.9 and 0.6, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> IgG aPS\/PT detection is an easily performed laboratory parameter that might contribute to a better and more complete identification of patients with APS. <\/jats:p><\/jats:sec>","DOI":"10.1177\/0961203316660203","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:19:00Z","timestamp":1470874740000},"page":"266-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study"],"prefix":"10.1177","volume":"26","author":[{"given":"O","family":"Amengual","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"given":"R","family":"Forastiero","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Traslacional, Trasplante y Bioingenier\u00eda (IMeTTyB), Universidad Favaloro-CONICET, Departamento de Fisiologia, Hemostasia y Trombosis, Buenos Aires, Argentina"}]},{"given":"M","family":"Sugiura-Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nagoya City University, Graduated School of Medical Sciences, Nagoya, Japan"}]},{"given":"K","family":"Otomo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"given":"K","family":"Oku","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"given":"C","family":"Favas","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Fernando Fonseca Hospital, Amadora and CEDOC\/NOVA Medical School, Lisbon, Portugal"}]},{"given":"J","family":"Delgado Alves","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, Fernando Fonseca Hospital, Amadora and CEDOC\/NOVA Medical School, Lisbon, Portugal"}]},{"given":"P","family":"\u017digon","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}]},{"given":"A","family":"Ambro\u017ei\u010d","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}]},{"given":"M","family":"Tom\u0161i\u010d","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}]},{"given":"I","family":"Ruiz-Arruza","sequence":"additional","affiliation":[{"name":"Autoimmune Diseases Research Unit, Department of Internal Medicine, Biocruces Health Research Institute, Hospital Universitario Cruces, University of The Basque Country, Spain"}]},{"given":"G","family":"Ruiz-Irastorza","sequence":"additional","affiliation":[{"name":"Autoimmune Diseases Research Unit, Department of Internal Medicine, Biocruces Health Research Institute, Hospital Universitario Cruces, University of The Basque Country, Spain"}]},{"given":"M L","family":"Bertolaccini","sequence":"additional","affiliation":[{"name":"Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, UK"}]},{"given":"G L","family":"Norman","sequence":"additional","affiliation":[{"name":"Inova Diagnostics Inc., San Diego, CA, USA"}]},{"given":"Z","family":"Shums","sequence":"additional","affiliation":[{"name":"Inova Diagnostics Inc., San Diego, CA, USA"}]},{"given":"J","family":"Arai","sequence":"additional","affiliation":[{"name":"Medical and Biological Laboratories, Co. 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