{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:05:57Z","timestamp":1777928757424,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this paper is to evaluate the performance of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) in detecting clinically meaningful changes in SLE disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal cohort study was conducted of 334 SLE patients during a 36-month follow-up. At each outpatient visit, disease activity was scored using the Physician Global Assessment (PGA) and SLEDAI-2K. Correlations between PGA and SLEDAI-2K were assessed. A clinically meaningful change in SLE disease activity was defined as a \u0394PGA\u2009\u2265\u20090.3 points from baseline. Performance of SLEDAI-2K in detecting a clinically meaningful worsening or improvement was tested using receiver operating characteristic (ROC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adjusted mean PGA and SLEDAI-2K scores presented a high correlation (rho\u2009=\u20090.824, p\u2009&lt;\u20090.0005). In ROC analysis, a SLEDAI-2K variation presented an area under the curve (AUC) of 0.697 (95% confidence interval (CI) (0.628\u20130.766), p\u2009&lt;\u20090.0005) to detect a clinically meaningful improvement, with a sensitivity of 28.8% for a SLEDAI-2K\u2009\u2265\u20094 reduction. The AUC to detect a clinically meaningful worsening was 0.877 (95% CI (0.822\u20130.932), p\u2009&lt;\u20090.0005), with a sensitivity of 35.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SLEDAI-2K has a limited ability to detect clinically meaningful changes in SLE disease activity, failing to identify almost two-thirds of cases judged as having a clinically meaningful improvement or worsening. There is a need for more sensitive SLE disease activity measures in clinical practice and research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203319836717","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T05:39:02Z","timestamp":1553146742000},"page":"607-612","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Performance of SLEDAI-2K to detect a clinically meaningful change in SLE disease activity: a 36\u2013month prospective cohort study of 334 patients"],"prefix":"10.1177","volume":"28","author":[{"given":"D","family":"Jesus","sequence":"first","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"M","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"A","family":"Matos","sequence":"additional","affiliation":[{"name":"School of Technology and Management, Polytechnic Institute of Viseu, Viseu, Portugal"},{"name":"Centre for the Study of Education, Technologies and Health, Viseu, Portugal"}]},{"given":"C","family":"Henriques","sequence":"additional","affiliation":[{"name":"School of Technology and Management, Polytechnic Institute of Viseu, Viseu, Portugal"},{"name":"Centre for the Study of Education, Technologies and Health, Viseu, Portugal"},{"name":"Centre for Mathematics, University of Coimbra, Coimbra, Portugal"}]},{"given":"J A","family":"Pereira da Silva","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}]},{"given":"L S","family":"In\u00eas","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"},{"name":"Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"bibr1-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"bibr2-0961203319836717","first-page":"288","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr3-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051135"},{"key":"bibr4-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1002\/art.24698"},{"key":"bibr5-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209519"},{"key":"bibr6-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207726"},{"key":"bibr7-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207347"},{"key":"bibr8-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex368"},{"key":"bibr9-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr10-0961203319836717","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"bibr11-0961203319836717","first-page":"1977","volume":"30","author":"Iba\u00f1ez D","year":"2003","journal-title":"J Rheumatol"},{"key":"bibr12-0961203319836717","unstructured":"R Development Core Team. 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