{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:42Z","timestamp":1777929222461,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Foundation for Science and Technology","award":["UI\/BD\/150742\/2020"],"award-info":[{"award-number":["UI\/BD\/150742\/2020"]}]},{"name":"UMIB","award":["UIDB\/00215\/2020; UIDP\/00215\/2020"],"award-info":[{"award-number":["UIDB\/00215\/2020; UIDP\/00215\/2020"]}]},{"name":"ITR","award":["LA\/P\/0064\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stress has been linked to worsening symptoms and increased disease activity in patients with Systemic lupus erythematosus (SLE). Life-events are individual stress points, and there is conflicting evidence regarding their role in SLE activity and disease perception.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult SLE patients were recruited for the study. Clinical and laboratory features of SLE were recorded, and previous diagnosis of anxiety or depression were retrieved from patients\u2019 electronic charts. Flares were defined by the Systemic Lupus Erythematosus Disease Activity (SLEDAI) flare Index, and flares during the previous year were documented. During a routine visit, they completed validated Portuguese translations of the 10-item Perceived Stress Scale (PSS-10), Hospital Anxiety and Depression Scale (HADS) and Life Experience Survey (LES) for the previous year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 47 female SLE patients were recruited. Ten patients (21.3%) had experienced recent flares. Patients with recent flares reported fewer life events, with lower positive, negative, and total weightings sums compared to those without recent flares. Although 42.2% of patients perceived pathological levels of stress in the previous month, 48.9% had anxiety symptoms, and 34% were at high risk for an anxiety disorder, these psychometric measures did not differ significantly between the recent flare and no-flare groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a high prevalence of pathological levels of stress among SLE patients. SLE patients with recent flares report less psychological impact from life events, both positive and negative, independent of other psychological or pharmacological factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033241266987","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T02:25:26Z","timestamp":1721615126000},"page":"1139-1144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Psychological impact of life events in systemic lupus erythematosus patients \u2013 Differences between flares and remission"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2956-1966","authenticated-orcid":false,"given":"Raquel","family":"Faria","sequence":"first","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica, Unidade Local de Sa\u00fade Santo Ant\u00f3nio (ULSSA), Porto, Portugal"},{"name":"Autoimmunity and Neurosciences Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal"},{"name":"ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal"}]},{"given":"Daniel","family":"Guimar\u00e3es de Oliveira","sequence":"additional","affiliation":[{"name":"Autoimmunity and Neurosciences Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal"},{"name":"ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal"},{"name":"Immunobiology Group, i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"},{"name":"Autoimmune Disease Unit, Internal Medicine Service, Unidade Local de Sa\u00fade do T\u00e2mega e Sousa, Penafiel, Portugal"}]},{"given":"Rute","family":"Alves","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina Intensiva Polivalente, Unidade Local de Sa\u00fade Gaia e Espinho, Vila Nova de Gaia, Portugal"}]},{"given":"F\u00e1tima","family":"Farinha","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica, Unidade Local de Sa\u00fade Santo Ant\u00f3nio (ULSSA), Porto, Portugal"},{"name":"Autoimmunity and Neurosciences Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal"},{"name":"ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal"}]},{"given":"Paulo","family":"Pinho Costa","sequence":"additional","affiliation":[{"name":"Autoimmunity and Neurosciences Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal"},{"name":"ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal"},{"name":"Human Genetics Department, Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, Porto, Portugal"}]},{"given":"Carlos","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica, Unidade Local de Sa\u00fade Santo Ant\u00f3nio (ULSSA), Porto, Portugal"},{"name":"Autoimmunity and Neurosciences Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal"},{"name":"ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal"}]},{"given":"Margarida","family":"Figueiredo-Braga","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health Department, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Metabesity Group, i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, University of Porto, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"bibr1-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.12.005"},{"key":"bibr2-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010418-102857"},{"key":"bibr3-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000133327.41044.94"},{"key":"bibr4-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1159\/000069735"},{"key":"bibr5-09612033241266987","doi-asserted-by":"publisher","DOI":"10.14195\/1647-8606_53_17"},{"key":"bibr6-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1080\/13548500500524088"},{"key":"bibr7-09612033241266987","first-page":"49","volume":"21","author":"Silva IP-RJL","year":"2003","journal-title":"Revista Portuguesa de Sa\u00fade P\u00fablica"},{"key":"bibr8-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3999(01)00296-3"},{"key":"bibr9-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006x.46.5.932"},{"key":"bibr10-09612033241266987","first-page":"288","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr11-09612033241266987","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-12_part_1-200506210-00004"},{"key":"bibr12-09612033241266987","first-page":"373","volume":"27","author":"Gladman DD","year":"2000","journal-title":"J Rheumatol"},{"key":"bibr13-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2021-000538"},{"key":"bibr14-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1007\/BF01857920"},{"key":"bibr15-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2023.6"},{"key":"bibr16-09612033241266987","doi-asserted-by":"publisher","DOI":"10.3928\/02793695-20180521-03"},{"key":"bibr17-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2011.02260.x"},{"key":"bibr18-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)00132-a"},{"key":"bibr19-09612033241266987","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab256"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241266987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033241266987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033241266987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:28:06Z","timestamp":1777678086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033241266987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/09612033241266987"],"URL":"https:\/\/doi.org\/10.1177\/09612033241266987","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,21]]}}}