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We report the case of 53-year-old women with a long history of SLE, diagnosed with CIDP during a lupus flare beginning with progressive muscle weakness of lower and upper limbs, without affection of the central nervous system. She received treatment with steroids, intravenous immunoglobulins and anifrolumab and showed clinical and immunological improvement. It is important to take into account the presence of peripheral neurological disorders in patients with SLE, considering CIDP as an uncommon manifestation. Controlling severe active disease is an imperative issue to manage this neurological manifestation which has a serious impact on health-related quality of life and physical function.<\/jats:p>","DOI":"10.1177\/09612033251314610","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T15:49:05Z","timestamp":1737128945000},"page":"312-315","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic inflammatory demyelinating polyneuropathy associated with active systemic lupus erythematous: Anifrolumab as a potentially successful add-on therapy to intravenous immunoglobulins"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4099-5973","authenticated-orcid":false,"given":"Carlos","family":"Marques-Gomes","sequence":"first","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Mariana","family":"Diz-Lopes","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Lu\u00eds","family":"Braz","sequence":"additional","affiliation":[{"name":"Neurology Department, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Ana","family":"Martins","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Daniela","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Rafaela","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"In\u00eas","family":"Santos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"L\u00facia","family":"Costa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Miguel","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3928\/00485713-20120906-05"},{"issue":"9","key":"e_1_3_4_3_2","first-page":"e17969","article-title":"Neuropsychiatric systemic lupus erythematosus: a 2021 update on diagnosis, management, and current challenges","volume":"13","author":"Sarwar S","year":"2021","unstructured":"Sarwar S, Mohamed AS, Rogers S, et al. 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