{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:07:16Z","timestamp":1777928836903,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate clinicopathological differences between screen-detected (SD) and interval (IC) breast cancers diagnosed in women enrolled in an organized breast screening programme in 2000--2007.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Breast Cancer Screening Programme of the north region of Portugal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from the screening programme and from the population-based North Region Cancer Registry, SD and IC were identified. Information on screening history, age, date of diagnosis, tumour size, histological type and grade, lymph node status, tumour stage, biomarkers, and treatment was obtained from the cancer registry and from clinical and pathological reports. Association between mode of detection and these clinicopathological characteristics was estimated by unconditional logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 442 SD and 112 IC were identified in women aged 50--69. Compared with SD, IC were diagnosed in younger women (60.0\u2009\u00b1\u20095.8 years and 58.4\u2009\u00b1\u20096.0 years, respectively), were larger (tumour size &gt;20\u2009mm: 60.2% versus 25.1%), lobular (6.3% versus 16.1%), with a higher differentiation grade (grade 3: 17.7% versus 38.9%), had more lymph node metastases, more advanced stage, and oestrogen receptor (ER) negative (12.9% versus 29.0%) and progesterone negative, and HER2 positive. After multivariable analysis, compared with SD, IC were more likely to be larger than 20\u2009mm, lobular, of grade 3 and negative for ER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results are consistent with other studies. IC\u2019s have a more aggressive biology than SDs. Our findings did not show any unexpected pattern requiring changes to our screening procedures, but continuous identification and characterization of IC is advisable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0969141314534406","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T00:32:47Z","timestamp":1399422767000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinicopathological differences between interval and screen-detected breast cancers diagnosed within a screening programme in Northern Portugal"],"prefix":"10.1177","volume":"21","author":[{"given":"Maria","family":"Jos\u00e9 Bento","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences Abel Salazar, University of Porto, and Epidemiology Unit, Portuguese Oncology Institute, Porto, Portugal"}]},{"given":"Guilherme","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal"}]},{"given":"Ana","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Portuguese Cancer League \u2013 North Branch, Porto, Portugal"}]},{"given":"Luis","family":"Antunes","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal"}]},{"given":"Vitor","family":"Veloso","sequence":"additional","affiliation":[{"name":"Portuguese Cancer League \u2013 North Branch, Porto, Portugal"}]},{"given":"V\u00edtor","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Coimbra, and Portuguese Cancer League \u2013 Centre Branch, Coimbra, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"key":"bibr1-0969141314534406","volume-title":"European guidelines for quality assurance in breast cancer screening and diagnosis","author":"Perry N","year":"2006","edition":"4"},{"key":"bibr2-0969141314534406","first-page":"181","volume-title":"Evaluation and Monitoring of Screening Programmes","author":"Stockton D","year":"2001"},{"key":"bibr3-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.3"},{"key":"bibr4-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32833548ed"},{"key":"bibr5-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1177\/096914130601300405"},{"key":"bibr6-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282f75ef5"},{"key":"bibr7-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9541-6"},{"key":"bibr8-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70617-9"},{"key":"bibr9-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.3.8638010"},{"key":"bibr10-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr138"},{"key":"bibr11-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.743"},{"key":"bibr12-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1304-1"},{"key":"bibr13-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602501"},{"key":"bibr14-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.23.2020"},{"key":"bibr15-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605317"},{"key":"bibr16-0969141314534406","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2012.012085"},{"key":"bibr17-0969141314534406","unstructured":"Statistics Portugal. 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