{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T05:34:38Z","timestamp":1740807278079,"version":"3.38.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacology and Pharmacotherapeutics"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p> In response to the COVID-19 pandemic, two mRNA vaccines (Comirnaty and Spikevax) received emergency use authorization from the European Medicines Agency. This case report aimed to report a delayed adverse reaction to the mRNA-1273 vaccine against COVID-19 from a Portuguese vaccination center. <\/jats:p><jats:p> A case report was performed with medical observation and reported to the Portuguese Pharmacovigilance System, then investigated based on the WHO-UMC Causality Categories. A 66-year-old female patient with a clinical history of dyslipidemia, essential arterial hypertension, obesity, multinodular goitre and cholecystectomy, who presented delayed large cutaneous hypersensitivity reaction following Spikevax COVID-19 mRNA (mRNA-1273) vaccine administration. <\/jats:p><jats:p> Our clinical findings (time and clinical appearance), along with evidence of previously reported histological findings, are strongly suggestive of T-cell-mediated hypersensitivity. There is no contraindication to the inoculation of subsequent doses in patients developing these clinical conditions, and vaccination should continue to be strongly encouraged. <\/jats:p>","DOI":"10.1177\/0976500x221147748","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T11:05:53Z","timestamp":1674126353000},"page":"401-403","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Delayed Extensive Local Reaction to the mRNA-1273 Vaccine against SARS-CoV-2: A Case Report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6517-6021","authenticated-orcid":false,"given":"Renato","family":"Ferreira-da-Silva","sequence":"first","affiliation":[{"name":"Porto Pharmacovigilance Centre, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Department of Community Medicine, Health Information and Decision, Faculty of Medicine of the University of Porto, Portugal"},{"name":"CINTESIS \u2013 Center for Health Technology and Services Research, Porto, Portugal"}]},{"given":"In\u00eas","family":"Ribeiro-Vaz","sequence":"additional","affiliation":[{"name":"Porto Pharmacovigilance Centre, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Department of Community Medicine, Health Information and Decision, Faculty of Medicine of the University of Porto, Portugal"},{"name":"CINTESIS \u2013 Center for Health Technology and Services Research, Porto, Portugal"}]},{"given":"Ana Marta","family":"Silva","sequence":"additional","affiliation":[{"name":"Porto Pharmacovigilance Centre, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"Department of Community Medicine, Health Information and Decision, Faculty of Medicine of the University of Porto, Portugal"},{"name":"CINTESIS \u2013 Center for Health Technology and Services Research, Porto, Portugal"}]},{"given":"Fernando","family":"Nunes","sequence":"additional","affiliation":[{"name":"Local Health Unit of Matosinhos, EPE, Matosinhos, Portugal"}]},{"given":"Manuela","family":"Morato","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of the University of Porto, Porto, Portugal"}]},{"given":"Jorge Junqueira","family":"Pol\u00f3nia","sequence":"additional","affiliation":[{"name":"Porto Pharmacovigilance Centre, Faculty of Medicine of the University of Porto, Porto, Portugal"},{"name":"CINTESIS \u2013 Center for Health Technology and Services Research, Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Paulo","family":"Guedes","sequence":"additional","affiliation":[{"name":"Local Health Unit of Matosinhos, EPE, Matosinhos, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"bibr1-0976500X221147748","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2102131"},{"issue":"24","key":"bibr2-0976500X221147748","volume":"384","author":"Baeck M","year":"2021","journal-title":"N Engl J Med"},{"key":"bibr3-0976500X221147748","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2108620"},{"key":"bibr4-0976500X221147748","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.092"},{"key":"bibr5-0976500X221147748","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.1214"},{"key":"bibr6-0976500X221147748","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab518"},{"key":"bibr7-0976500X221147748","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2022.43.210101"},{"key":"bibr8-0976500X221147748","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14104"},{"key":"bibr9-0976500X221147748","unstructured":"Centre UM. 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