{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:53:58Z","timestamp":1764996838036,"version":"3.38.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T00:00:00Z","timestamp":1215475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p> In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 adenoma with clear cell dysplastic glands progressed to adenocarcinoma without clear cell change. Clear cell cytoplasmatic vacuoles were negative for glycogen and mucins (MUC 2, MUC 5AC). Ki-67 LI in clear cell adenoma components was lower than in common adenoma components of the same dysplasia grades (while p53 and \u03b2-catenin were similarly expressed). Ultrastructural features of clear cell change showed features of lipid-like material. Clear cell change is found in hyperplastic and neoplastic lesions of the colon and is not due to the accumulation of glycogen or mucins. A degenerative nature of clear cell change is suggested by the demonstration of lipid-like material in the vacuoles of clear cells. <\/jats:p>","DOI":"10.1177\/1066896908319211","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T04:52:30Z","timestamp":1215579150000},"page":"438-443","source":"Crossref","is-referenced-by-count":16,"title":["Clear Cell Change in Colonic Polyps"],"prefix":"10.1177","volume":"17","author":[{"given":"Catarina","family":"Eloy","sequence":"first","affiliation":[{"name":"Department of Pathology, Hospital de S. Jo\u00e3o, Institute of Molecular Pathology and Immunology of the University of Porto"}]},{"given":"Jos\u00e9 M.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital de S. 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