{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:11:44Z","timestamp":1777716704805,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T00:00:00Z","timestamp":1243555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Endometrial stromal sarcomas (ESSs) are rare tumors whose classification is still controversial. In this study, the authors studied 19 patients diagnosed with ESS at the Hospital S Jo\u00e3o, Porto, Portugal; reviewed their files and material; and performed immunohistochemical study for CD10, desmin, and smooth muscle actin markers, aiming to compare low-grade endometrial stromal sarcomas (LG-ESSs) and undifferentiated endometrial sarcomas (UESs) using the World Health Organization (WHO) classification. Twelve cases (63%) were classified as LG-ESS and 7 (37%) as UES. The median age at diagnosis was 49 years, and women with LG-ESS tended to be younger than those with UES. Most cases (7\/11) had a previous echographic diagnosis of leiomyoma. A biopsy or curettage was performed in 6 cases, providing a definitive diagnosis of malignancy in 4. Frozen section was performed in 4 patients. The majority (63%) of patients were FIGO stage I. Twelve (63%) cases showed diffuse or focal expression of CD10. Desmin and smooth muscle actin expression was focal in 4 (21%) tumors. Patients with LG-ESS had a significant better overall survival than those with UES ( P = .026). Mitotic count had no prognostic significance. Our data emphasize the clinical importance of the WHO classification in ESS. It is of utmost importance to establish a proper classification to increase the consistency of data that may be useful for improving clinical and therapeutic management of patients with ESS.<\/jats:p>","DOI":"10.1177\/1066896909337600","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T20:24:43Z","timestamp":1243628683000},"page":"286-291","source":"Crossref","is-referenced-by-count":27,"title":["Low-Grade Endometrial Stromal Sarcoma and Undifferentiated Endometrial Sarcoma: A Comparative Analysis Emphasizing the Importance of Distinguishing Between These Two Groups"],"prefix":"10.1177","volume":"18","author":[{"given":"Carla","family":"Bartosch","sequence":"first","affiliation":[{"name":"Department of Pathology, Hospital S\u00e3o Joao"}]},{"given":"Maria Isabel","family":"Exposito","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital S\u00e3o Joao, Department of Pathology, Medical Faculty, University of Porto"}]},{"given":"Jos\u00e9 Manuel","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital S\u00e3o Joao, , Department of Pathology, Medical Faculty, University of Porto, IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2009,5,29]]},"reference":[{"key":"atypb1","unstructured":"Anderson MC, Robboy SJ, Russel P. Endometrial stromal tumours. In: Robboy SJ, Anderson MC, Russel P, eds. Pathology of the Female Reproductive Tract . London, UK: Harcourt Health Sciences ; 2002:361-369."},{"key":"atypb2","unstructured":"Hendrickson MR , Tavassoli FA, Kempson RL, et al. Mesenchymal tumours and related lesions . In: Tavassoli FA, Devilee P, eds. WHO Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003:233-244."},{"key":"atypb3","unstructured":"Rollason TP, Wilkinson N. Non-neoplastic conditions of the myometrium and pure mesenchymal tumours of the uterus. In: Fox H, Wells H, eds. Haines & Taylor Obstetrical and Gynaecological Pathology. Edinburgh, UK: Elsevier Science; 2003:497-548."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196606)19:6<755::AID-CNCR2820190604>3.0.CO;2-U"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199005000-00002"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0314"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609054670"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6152"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00078-2"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-4-50"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.01.031"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0224"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.10.023"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200206000-00010"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1159\/000080283"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.10.021"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00207-5"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1309\/G13Y360MTXLN7KU9"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)00580-X"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5598"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.031203"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1054\/cdip.2002.0126"},{"key":"atypb23","unstructured":"Rahaman J., Cohen CJ Gynecological sarcomas. In: Kufe DW, Pollock RE, Weischselbaum RR, Bast RC, Gansler TS, eds. Holland, Frei Cancer Medicine 6. London, UK: BC Decker; 2003:1871-1878."},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdip.2004.11.007"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200102000-00014"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200106000-00009"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880335"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00004"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01384.x"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200201000-00008"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.08.038"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01215.x"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197708)40:2<898::AID-CNCR2820400246>3.0.CO;2-X"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<2170::AID-CNCR2820501033>3.0.CO;2-K"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60568-5"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816a3b42"},{"key":"atypb37","volume-title":"Uterine Neoplasms. V.I.2008","author":"NCCN Clinical Practice Guidelines in Oncology.","year":"2009"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.07.021"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200007050-00001"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896909337600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896909337600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:19:35Z","timestamp":1777457975000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896909337600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,29]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1177\/1066896909337600"],"URL":"https:\/\/doi.org\/10.1177\/1066896909337600","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,29]]}}}