{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:36:13Z","timestamp":1761708973563,"version":"3.38.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p> In the thyroid, primary neuroendocrine tumors encompass medullary thyroid carcinoma (MTC) and, rarely, other tumors such as paragangliomas. MTCs are derived from C-cells and express calcitonin and neuroendocrine markers. Besides classic MTC, some reports have documented thyroid neuroendocrine tumors, which show no calcitonin expression and raise difficult diagnostic problems. A 76-year-old man presented with a mass in the left thyroid with neither serological calcitonin elevation nor familial history. A thorough clinico-laboratorial study did not disclose any other mass elsewhere. A left hemithyroidectomy was performed, and the histological examination revealed a neuroendocrine carcinoma resembling a paraganglioma-like MTC displaying unequivocal signs of vascular invasion. Immunohistochemically, the tumor cells showed reactivity for chromogranin A, synaptophysin, thyroid transcription factor-1 (TTF-1), paired box gene 8 (PAX8), cytokeratins (AE1\/AE3 and CK8\/18), and calcitonin gene-related peptide (CGRP) and negativity for calcitonin, carcinoembryonic antigen, TTF-2, thyroperoxidase, and thyroglobulin. In situ hybridization showed that the tumor cells lacked expression for calcitonin and thyroglobulin mRNA. Genetic analysis did not disclose any RET mutation. A diagnosis of C-cell-derived primary neuroendocrine carcinoma of the thyroid without calcitonin expression was made, and the patient remains free of metastasis or recurrence 18 months after surgery. <\/jats:p>","DOI":"10.1177\/1066896914525228","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T01:58:13Z","timestamp":1394071093000},"page":"530-535","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["C-Cell-Derived Calcitonin-Free Neuroendocrine Carcinoma of the Thyroid"],"prefix":"10.1177","volume":"22","author":[{"given":"Tadao","family":"Nakazawa","sequence":"first","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal"},{"name":"University of Yamanashi, Yamanashi, Japan"}]},{"given":"Jos\u00e9","family":"Cameselle-Teijeiro","sequence":"additional","affiliation":[{"name":"University of Santiago de Compostela, IDIS, Spain"}]},{"given":"Jo\u00e3o","family":"Vinagre","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal"}]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal"},{"name":"Medical Faculty of the University of Porto, Porto, Portugal"}]},{"given":"Emmanuel","family":"Rousseau","sequence":"additional","affiliation":[{"name":"CHMouscron, Mouscron, Belgium"}]},{"given":"Catarina","family":"Eloy","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal"},{"name":"Central Hospital of S Jo\u00e3o, Porto, Portugal"},{"name":"University of Porto, Porto, Portugal"}]},{"given":"Manuel","family":"Sobrinho-Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal"},{"name":"Medical Faculty of the University of Porto, Porto, Portugal"},{"name":"Central Hospital of S Jo\u00e3o, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"bibr1-1066896914525228","first-page":"86","volume-title":"Pathology and Genetics of Tumours of Endocrine Organs. 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