{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:06:50Z","timestamp":1777716410653,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,4,1]],"date-time":"1995-04-01T00:00:00Z","timestamp":796694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:p>To investigate the expression of a marker of cell proliferation (MIB-1) and its puta tive relationship with tumor size, histologic grading, mitotic index, nodal status, estrogen receptor content, p53 immunoreactivity, and ploidy, we studied 40 cases of invasive breast carcinoma in formalin-fixed, paraffin-embedded tissue sections. The MIB-1, estrogen receptor, and p53 were detected using an avidin-biotin-peroxidase method with microwave antigen retrieval. Ploidy was assessed by image analysis. The median value of MIB-1 index was 15.9% and ranged from 5% to 90%. We found a significant and positive relationship among the MIB-1 index and histologic grading, mitotic index, p53 immunoreactivity, and ploidy, and we demonstrated an inverse relationship between the MIB-1 index and estrogen receptor content. These \" results are similar to those reported using Ki-67 in frozen sections from breast car cinomas. Thus, MIB-1 detected in formalin-fixed material with microwave pre treatment looks to be a reliable marker of proliferation in breast carcinomas. Int J Surg Pathol 2(4):287-294, 1995<\/jats:p>","DOI":"10.1177\/106689699500200405","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:41:40Z","timestamp":1196098900000},"page":"287-293","source":"Crossref","is-referenced-by-count":15,"title":["MIB-1 Is a Suitable Marker of Proliferative Activity in Formalin-fixed, Paraffin-embedded Sections of Breast Cancer"],"prefix":"10.1177","volume":"2","author":[{"given":"Fernando Carlos","family":"Schmitt","sequence":"first","affiliation":[{"name":"Botucatu School of Medicine, UNESP, Botucatu, S\u00e3o Paulo"}]},{"given":"Marcia Pitombeira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cear\u00e1, Brazil."}]}],"member":"179","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"atypb1","first-page":"107","volume":"134","author":"Kamel OW","year":"1989","journal-title":"Am J Pathol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.1.41"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900301)65:5<1180::AID-CNCR2820650525>3.0.CO;2-7"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.5.416"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930601)71:11<3552::AID-CNCR2820711115>3.0.CO;2-N"},{"key":"atypb6","first-page":"39","volume":"424","author":"Haerslev T.","year":"1994","journal-title":"Virchows Arch [A]"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80426-7"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.1.30"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3109\/00313029109063589"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.200"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910801)68:3<549::AID-CNCR2820680318>3.0.CO;2-J"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910115)67:2<421::AID-CNCR2820670217>3.0.CO;2-Q"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/98.4.408"},{"key":"atypb14","first-page":"867","volume":"138","author":"Gerdes J.","year":"1991","journal-title":"Am J Pathol"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00135.x"},{"key":"atypb16","first-page":"629","volume":"68","author":"Key G.","year":"1993","journal-title":"Lab Invest"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1957.43"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0046-8177(92)90313-R","volume":"23","author":"Van Diest PJ","year":"1992","journal-title":"Hum Pathol"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460515"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90284-M"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711620403"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1038\/326515a0"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1992.tb00454.x"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870515)59:10<1744::AID-CNCR2820591012>3.0.CO;2-D"},{"key":"atypb25","first-page":"1115","volume":"136","author":"Dawson AE","year":"1990","journal-title":"Am J Pathol"},{"key":"atypb26","first-page":"296","volume":"144","author":"Hirano T.","year":"1994","journal-title":"Am J Pathol"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106689699500200405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106689699500200405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:18:17Z","timestamp":1777457897000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106689699500200405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,4]]}},"alternative-id":["10.1177\/106689699500200405"],"URL":"https:\/\/doi.org\/10.1177\/106689699500200405","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}