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Abnormal E-cadherin expression was significantly (p=.0007) higher in diffuse\/isolated-cell type carcinomas than in intestinal\/glandular carcinomas. In mixed carcinomas abnormal E-cadherin expression in the diffuse\/isolated-cell-type component (94.4%) was significantly (p=.007) higher than in intestinal\/glandular component (55.6%). Significant relationships were observed between abnormal E-cadherin expression and nodal metastases (p=.004) and pTNM stages (p=.05). Survival of patients with tumors displaying abnormal E-cadherin expression was worse than that of patients with tumors presenting normal expression, though not attaining the threshold of statistical significance (p=.l9). We conclude that abnormal E-cadherin expression is correlated with diffuse\/isolated-cell histotype and features of biological aggressiveness of gastric carcinoma.<\/jats:p>","DOI":"10.1177\/106689699800600302","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:50:28Z","timestamp":1182462628000},"page":"135-144","source":"Crossref","is-referenced-by-count":18,"title":["E-Cadherin Expression Is Correlated with the Isolated Cell\/Diffuse Histotype and with Features of Biological Aggressiveness of Gastric Carcinoma"],"prefix":"10.1177","volume":"6","author":[{"given":"Jos\u00e9 C.","family":"Machado","sequence":"first","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), Medical Faculty, Porto, Portugal; IPATIMUP, Rua Roberto Frias, s\/n, 4200 Porto, Portugal"}]},{"given":"F\u00e1itima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), Medical Faculty, Porto, Portugal"}]},{"given":"Stefanie","family":"Beck","sequence":"additional","affiliation":[{"name":"Institute for Anthropology and Human Genetics, University of T\u00fcbingen, T\u00fcbingen, Germany"}]},{"given":"Simone","family":"Rossi","sequence":"additional","affiliation":[{"name":"Health Secretary of the State of Rio Grande do Sul, Porto Alegre, RS, Brazil"}]},{"given":"Joanne","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pathology, H. 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