{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:55:21Z","timestamp":1790996121879,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R00-CA218603"],"award-info":[{"award-number":["R00-CA218603"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Control"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Aerobic exercise improves disease-free and overall survival in patients with colorectal cancer. This study tested the hypothesis that a key mechanism of action underpinning these survival benefits relates to exercise-induced improvements in inflammation and immunity in colorectal cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This trial randomized 60 survivors of stage I-III colorectal cancer to 12 weeks of home-based aerobic exercise or control. Endpoints included plasma sCD30, sGP130, IL-1\u03b2, and IL-2 measured using bead-based magnetic immunoassays, and the frequencies of circulating T-cell [CD4+ and CD8+ na\u00efve, central memory, effector memory, and terminally differentiated effector memory (TEMRA)] and NK-cell subsets quantified by flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exercise training reduced sCD30 [\u2212153.1 pg\/mL (95% CI: \u2212249.5, \u221256.7); p=0.014] but did not reduce sGP130, IL-1\u03b2, or IL-2 compared to control. Exercise training increased the proportions of resting NKG2D\u2212\/NKG2C+ NK-cells [2.75% (95% CI: 0.34, 5.15); p=0.03] and CD56+ bright KLRG1\u2212\/NKG2C+ NK-cells [4.46% (95% CI: 1.32, 7.60); p=0.006] compared to control. In the control group, sCD30 inversely correlated with naive CD8+ T-cells [r=\u22120.51 (95% CI: \u22120.82, 0.03); p=0.04], whereas sGP130 [r=0.46 (95% CI: \u22120.09, 0.72); p=0.01] and IL-2 positively correlated with CD8+ TEMRA frequencies [r=0.50 (95% CI: 0.06, 0.78); p=0.02]; these associations were not statistically significant in the exercise group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this secondary, exploratory analysis of a randomized trial, aerobic exercise reshaped aspects of the inflammatory-immune axis in colorectal cancer survivors. These findings refine our understanding of the biological mechanisms by which exercise may improve disease-free and overall survival in colon cancer survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10732748261493127","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:17:51Z","timestamp":1790680671000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Aerobic Exercise on Circulating T-Cells and NK-Cells in Colorectal Cancer Survivors: A Secondary Analysis of a Randomized Trial"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-2932","authenticated-orcid":false,"given":"Eunhan","family":"Cho","sequence":"first","affiliation":[{"name":"AdventHealth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L. 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