{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:08:07Z","timestamp":1771556887965,"version":"3.50.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p> Methylenetetrahydrofolate reductase ( MTHFR) gene polymorphism (C677T)] is a well-recognized genetic risk factor for venous thrombosis; however, its association with arterial thrombosis is still under debate. Herein, we evaluated the prevalence of MTHFR C677T polymorphism in Georgian patients in comparison with healthy individuals and its association with arterial thrombosis. We enrolled 214 participants: 101 with arterial thrombosis (71.3% males; mean age: 66.3 \u00b1 12.1 years) and 113 controls (67.3% males; mean age: 56.6 \u00b1 11.3 years). Genomic DNA was extracted from dry blood spot on Whatman filter paper. Polymerase chain reaction was performed to determine MTHFR C677T polymorphism. Frequency of C677T allele polymorphism in controls was 21.2%, which corresponded to heterozygous and homozygous stage frequencies of 35.4% and 3.5%, respectively. In patient group, an allelic frequency of 33.2% was found, which corresponded to the presence of 48.5% of heterozygous and 8.9% of homozygous individuals. Comparing the frequency of mutated alleles between the 2 groups, a significantly high frequency of mutated alleles was found in patient group ( P &lt; .05). In conclusion, high frequency of MTHFR C677T polymorphism found in arterial thrombosis patient group suggests that this polymorphism might increase the risk of arterial thrombosis in Georgian patients. <\/jats:p>","DOI":"10.1177\/1076029618757345","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T04:43:13Z","timestamp":1518583393000},"page":"1061-1066","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients"],"prefix":"10.1177","volume":"24","author":[{"given":"Sopio","family":"Garakanidze","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia"}]},{"given":"El\u00edsio","family":"Costa","sequence":"additional","affiliation":[{"name":"Research Unit on Applied Molecular Biosciences (UCIBIO), Rede de Qu\u00edmica e Tecnologia (REQUIMTE), Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Elsa","family":"Bronze-Rocha","sequence":"additional","affiliation":[{"name":"Research Unit on Applied Molecular Biosciences (UCIBIO), Rede de Qu\u00edmica e Tecnologia (REQUIMTE), Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Research Unit on Applied Molecular Biosciences (UCIBIO), Rede de Qu\u00edmica e Tecnologia (REQUIMTE), Faculty of Pharmacy, University of Porto, Porto, Portugal"}]},{"given":"Giorgi","family":"Nikolaishvili","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia"}]},{"given":"Irina","family":"Nakashidze","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia"}]},{"given":"Nona","family":"Kakauridze","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia"}]},{"given":"Salome","family":"Glonti","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia"}]},{"given":"Rusudan","family":"Khukhunaishvili","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia"}]},{"given":"Marina","family":"Koridze","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia"}]},{"given":"Sarfraz","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Florida Hospital Cancer Institute, Orlando, FL, USA"}]}],"member":"179","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"bibr1-1076029618757345","doi-asserted-by":"publisher","DOI":"10.4238\/2011.October.25.7"},{"key":"bibr2-1076029618757345","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872396"},{"key":"bibr3-1076029618757345","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3019"},{"key":"bibr4-1076029618757345","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"issue":"7","key":"bibr5-1076029618757345","first-page":"17","volume":"59","author":"Kadziela J","year":"2003","journal-title":"Kardiol 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