{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:08Z","timestamp":1777581308016,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T00:00:00Z","timestamp":1676160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Since very preterm children often have increased retinal tortuosity that may indicate decisive architectural changes in the systemic microvascular network, we used a new semi-automatic software to measure retinal vessel tortuosity on fundus digital images of moderate-to-late preterm (MLP) children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational case-control study, the global and local tortuosity parameters of retinal vessels were evaluated on fundus photographs of 36 MLP children and 36 age- and sex-matched controls. The associations between birth parameters and parameters reflecting retinal vessel tortuosity were evaluated using correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Even after incorporation of anatomical factors, the global and local tortuosity parameters were not significantly different between groups. The MLP group showed a smaller arteriolar caliber (0.53\u2009\u2009\u00b1\u2009\u20090.2) than the controls (0.56\u2009\u2009\u00b1\u2009\u20090.2; p\u2009\u2009=\u2009\u20090.013). Other local tortuosity parameters, such as vessel length, distance to fovea, and distance to optic disc, were not significantly different between arteries and veins. Tortuosity in both groups was higher among vessels closer to the fovea (r\u2009\u2009=\u2009\u2009-0.077, p\u2009&lt;\u20090.001) and the optic disc (r\u2009\u2009=\u2009\u2009-0.0544, p\u2009\u2009=\u2009\u20090.009). Global tortuosity showed a weakly positive correlation with gestational age and a weakly negative correlation with birth weight in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MLP patients did not display increased vessel tortuosity in comparison with the controls; however, the arteriolar caliber in the MLP group was smaller than that in children born full-term. Larger studies should confirm this finding and explore associations between cardiovascular and metabolic status and retinal vessel geometry in MLP children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231157262","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:44:21Z","timestamp":1676249061000},"page":"1874-1882","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Computer-assisted evaluation of retinal vessel tortuosity in moderate-to-late preterm children"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-2353","authenticated-orcid":false,"given":"Lina","family":"Raffa","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"},{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}]},{"given":"Ola","family":"Abudawd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}]},{"given":"Nada","family":"Bugshan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}]},{"given":"Samiha","family":"Fageeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}]},{"given":"Lucia","family":"Ramos","sequence":"additional","affiliation":[{"name":"VARPA Research Group, Instituto de Investigacion Biomedica de A Coruna (INIBIC), Universidade da Coruna, A Coruna, Spain"}]},{"given":"Jorge","family":"Novo","sequence":"additional","affiliation":[{"name":"Centro de Investigacion CITIC, Universidade da Coruna, A Coruna, Spain"},{"name":"VARPA Research Group, Instituto de Investigacion Biomedica de A Coruna (INIBIC), Universidade da Coruna, A Coruna, Spain"}]},{"given":"Jose","family":"Rouco","sequence":"additional","affiliation":[{"name":"Centro de Investigacion CITIC, Universidade da Coruna, A Coruna, Spain"},{"name":"VARPA Research Group, Instituto de Investigacion Biomedica de A Coruna (INIBIC), Universidade da Coruna, A Coruna, Spain"}]},{"given":"Marcos","family":"Ortega","sequence":"additional","affiliation":[{"name":"Centro de Investigacion CITIC, Universidade da Coruna, A Coruna, Spain"},{"name":"VARPA Research Group, Instituto de Investigacion Biomedica de A Coruna (INIBIC), Universidade da Coruna, A Coruna, Spain"}]}],"member":"179","published-online":{"date-parts":[[2023,2,12]]},"reference":[{"key":"bibr1-11206721231157262","unstructured":"Ministry of Health of Saudi Arabia. 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