{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:38:28Z","timestamp":1777581508672,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018446","name":"Alimera Sciences","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/100018446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Persistent diabetic macular edema (DME) remains a problem in clinical practice, with many patients having a suboptimal response to the standard of care (SOC). Evidence supports the long-term efficacy of intravitreal fluocinolone acetonide (FAc) implant (ILUVIEN\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) in patients that have responded sub-optimally, although there is still scarce data from real-world Portuguese practices. We aimed to monitor the current SOC in selected Portuguese practices prior to FAc implantation and then assess the long-term effectiveness and safety of the FAc implant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings<\/jats:title>\n                    <jats:p>The study included patient data from five Portuguese public hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a non-interventional, multicenter audit of data collected from Retina.pt registry from patients with persistent or recurrent DME despite treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Outcome measures included changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP). Results were compared at regular times over 36 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 222 eyes from 152 patients. A significant decrease in BCVA (P\u2009&lt;\u20090.001) and a significant increase in CMT (P\u2009=\u20090.013) were observed prior to FAc. A significant increase in BCVA was registered at 6 months after FAc implant administration (P\u2009&lt;\u20090.001), which was maintained during follow-up. No relevant changes in IOP were observed. Treatment burden was reduced as a result of treatment with FAc (P\u2009&lt;\u20090.001 for anti-VEGF, corticosteroids, or both treatments) in the full population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Portuguese practice, data showed that pre-FAc implantation, some patients did not respond to SOC treatment and\/or they were undertreated. Following FAc implant administration, there were rapid, sustained, long-term visual and anatomical improvements, and a marked reduction in treatment burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231217525","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T03:35:04Z","timestamp":1701142504000},"page":"1149-1158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["ILUVIEN\n                    <sup>\u00ae<\/sup>\n                    in diabetic macular edema that persists or recurs despite treatment: Results from the Retina.pt\n                    <sup>\u00ae<\/sup>\n                    RIVER audit"],"prefix":"10.1177","volume":"34","author":[{"given":"Carla","family":"Teixeira","sequence":"first","affiliation":[{"name":"Department of Ophthalmology of Hospital Pedro Hispano, Unidade Local de Sa\u00fade de Matosinhos, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-1561","authenticated-orcid":false,"given":"Bernardete","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Diabetes Ocular Department of Centro Hospitalar e Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Porto, Portugal"},{"name":"Department of Ophthalmology, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute for the Biomedical Sciences Abel Salazar from University of Porto (UMIB ICBAS - UP), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-0164","authenticated-orcid":false,"given":"Miguel","family":"Ru\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology of Centro Hospitalar entre Douro e Vouga, Santa Maria da Feira, Portugal"}]},{"given":"Jo\u00e3o Paulo Castro","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology of Centro Hospitalar de Leiria, Leiria, Portugal"}]},{"given":"Susana","family":"Penas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology of Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o (CHUSJ), E.P.E., Porto, Portugal"},{"name":"Department of Ophthalmology of Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ophthalmology Clinic, Faculty of Medicine of the University of Coimbra (FMUC), Coimbra, \rPortugal"},{"name":"Department of Ophthalmology of Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"},{"name":"Department of Ophthalmology, Coimbra, Centro Acad\u00e9mico Cl\u00ednico de Coimbra (CACC), Coimbra, Portugal"}]},{"given":"\u00c2ngela","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology of Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o (CHUSJ), E.P.E., Porto, Portugal"}]},{"given":"Angelina","family":"Meireles","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology of Centro Hospitalar e Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Porto, 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