{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:04:08Z","timestamp":1777935848301,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>This work aimed to study the association between fibrinolytic\/endothelial cell function and inflammatory markers in chronic kidney disease (CKD) patients undergoing hemodialysis (HD) and recombinant human erythropoietin (rhEPO) therapies, and its relationship with the type of vascular access (VA) used for the HD procedure. As fibrinolytic\/endothelial cell function markers we evaluated plasminogen activator inhibitor type-1 (PAI-1), tissue plasminogen activator (tPA) and D-dimers, and as inflammatory markers; C-reactive protein (CRP), soluble interleukin (IL)-2 receptor (s-IL2R), IL-6 and serum albumin levels. The study was performed in 50 CKD patients undergoing regular HD, 11 with a central venous dialysis catheter (CVC) and 39 with an arteriovenous fistula (AVF), and in 25 healthy controls. Compared to controls, CKD patients presented with significantly higher levels of CRP, s-IL2R, IL-6 and D-dimers, and significantly lower levels of PAI-1. The tPA\/PAI-1 ratio was significantly higher in CKD patients. We also found statistical significant correlations in CKD patients between D-dimers levels and inflammatory markers: CRP, albumin, s-IL2R and IL-6. When comparing the two groups of CKD patients, we found that those with a CVC presented statistically significant lower levels of hemoglobin concentration and albumin, and higher levels of CRP, IL-6, D-dimers and tPA. Our results showed an association between fibrinolytic\/endothelial cell function and increased inflammatory markers in CKD patients. The increased levels of D-dimer, tPA and inflammatory markers in CKD patients using a CVC, led us to propose a relationship between the type of VA chosen for HD, and the risk of thrombogenesis.<\/jats:p>","DOI":"10.1177\/112972980800900405","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T05:22:15Z","timestamp":1520918535000},"page":"248-253","source":"Crossref","is-referenced-by-count":32,"title":["Cross-Talk between Inflammation, Coagulation\/Fibrinolysis and Vascular access in Hemodialysis Patients"],"prefix":"10.1177","volume":"9","author":[{"given":"E.","family":"Costa","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade da Universidade Cat\u00f3lica Portuguesa, Porto - Portugal"},{"name":"Faculdade Farm\u00e1cia, Servi\u00e7o de Bioqu\u00edmica, Universidade do Porto - Portugal"},{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto - Portugal"}]},{"given":"S.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Faculdade Farm\u00e1cia, Servi\u00e7o de Bioqu\u00edmica, Universidade do Porto - Portugal"},{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto - Portugal"}]},{"given":"P.","family":"Rocha-Pereira","sequence":"additional","affiliation":[{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto - Portugal"},{"name":"Centro Investiga\u00e7\u00e3o Ci\u00eancias Sa\u00fade, Universidade Beira Interior, Covilh\u00e3 - Portugal"}]},{"given":"E.","family":"Castro","sequence":"additional","affiliation":[{"name":"Faculdade Farm\u00e1cia, Servi\u00e7o de Bioqu\u00edmica, Universidade do Porto - Portugal"},{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto - Portugal"}]},{"given":"F.","family":"Reis","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Terap\u00eautica Experimental, Faculdade Medicina, Universidade Coimbra - Portugal"}]},{"given":"F.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto de Farmacologia e Terap\u00eautica Experimental, Faculdade Medicina, Universidade Coimbra - Portugal"}]},{"given":"V.","family":"Miranda","sequence":"additional","affiliation":[{"name":"FMC, Dinefro - Di\u00e1lises e Nefrologia, SA - Portugal"}]},{"given":"M. Do Sameiro","family":"Faria","sequence":"additional","affiliation":[{"name":"FMC, Dinefro - Di\u00e1lises e Nefrologia, SA - Portugal"}]},{"given":"A.","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Uninefro \u2013 Sociedade Prestadora de cuidados M\u00e9dicos e de Di\u00e1lise, SA - Portugal"}]},{"given":"A.","family":"Quintanilha","sequence":"additional","affiliation":[{"name":"Faculdade Farm\u00e1cia, Servi\u00e7o de Bioqu\u00edmica, Universidade do Porto - Portugal"},{"name":"Instituto Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto - Portugal"}]},{"given":"L.","family":"Belo","sequence":"additional","affiliation":[{"name":"Faculdade Farm\u00e1cia, Servi\u00e7o de Bioqu\u00edmica, Universidade do Porto - Portugal"},{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto - Portugal"}]},{"given":"A.","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Faculdade Farm\u00e1cia, Servi\u00e7o de Bioqu\u00edmica, Universidade do Porto - Portugal"},{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto - Portugal"}]}],"member":"179","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"bibr1-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.07603.x"},{"key":"bibr2-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1159\/000168982"},{"key":"bibr3-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00409.x"},{"key":"bibr4-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.8269"},{"key":"bibr5-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1177\/112972980200300204"},{"key":"bibr6-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.1.17"},{"key":"bibr7-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2002.kid556.x"},{"key":"bibr8-112972980800900405","first-page":"545","volume":"29","author":"Fishbane S.","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"bibr9-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9168-x"},{"key":"bibr10-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1159\/000084654"},{"key":"bibr11-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.61.s80.18.x"},{"key":"bibr12-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.08.014"},{"key":"bibr13-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1080\/00365510310000989"},{"key":"bibr14-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl845"},{"key":"bibr15-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002481"},{"key":"bibr16-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70333-1"},{"key":"bibr17-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.8.2019"},{"key":"bibr18-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2004.09.001"},{"key":"bibr19-112972980800900405","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2005.018"},{"key":"bibr20-112972980800900405","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1681\/ASN.V1261255","volume":"12","author":"Segarra A.","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"bibr21-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.06.004"},{"key":"bibr22-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.02.012."},{"key":"bibr23-112972980800900405","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134965.73212.A6"}],"container-title":["The Journal of Vascular Access"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112972980800900405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112972980800900405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:11:07Z","timestamp":1777691467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112972980800900405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1177\/112972980800900405"],"URL":"https:\/\/doi.org\/10.1177\/112972980800900405","relation":{},"ISSN":["1129-7298","1724-6032"],"issn-type":[{"value":"1129-7298","type":"print"},{"value":"1724-6032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}