{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:27:47Z","timestamp":1777465667183,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomark\ufffdInsights"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a nonfunctional peptide, soon after, UAG has been associated to an insulin sensitizing action and to a negative action on energy balance. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from eventual influence of anthropometrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred lean and 254 obese Caucasian women were studied. Each woman was characterized for anthropometrics, fasting glucose, insulin, HbA1c, and UAG. In addition, obese women were subjected to a classic oral glucose tolerance test (oGTT) to assess glucose and insulin at 120\u2009minutes. Insulin resistance was assessed by the homeostasis model assessment (HOMA-IR). Obese women were classified in 3 glycemic status subgroups (normoglycemia, prediabetes, and diabetes) according to HbA1c and to fasting and oGTT glucose values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In comparison with the lean group, significantly lower levels of UAG were observed in obese women. However, no significant difference was observed through obesity classes I to III. UAG levels were not significantly different among glycemic status subgroups and did not show any association with glucose, insulin, HOMA-IR, or HbA1c.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although anthropometry can influence the level of the unacylated form of ghrelin, UAG plasma levels do not associate to glucose homeostasis parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1177271920928923","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T14:50:04Z","timestamp":1591368604000},"page":"117727192092892","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Glucose Homeostasis in Obese Women Is Not Associated to Unacylated Ghrelin Plasma Levels"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-8343","authenticated-orcid":false,"given":"Luisa","family":"Veiga","sequence":"first","affiliation":[{"name":"Health and Technology Research Center (H&TRC), Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, Lisbon, Portugal"}]},{"given":"Miguel","family":"Brito","sequence":"additional","affiliation":[{"name":"Health and Technology Research Center (H&TRC), Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, Lisbon, Portugal"}]},{"given":"Carina","family":"Silva","sequence":"additional","affiliation":[{"name":"Health and Technology Research Center (H&TRC), Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, Lisbon, Portugal"},{"name":"Centro de Estat\u00edstica e Aplica\u00e7\u00f5es, Faculdade de Ci\u00eancias, Universidade de Lisboa, Lisboa, Portugal"}]},{"given":"Jos\u00e9","family":"Silva-Nunes","sequence":"additional","affiliation":[{"name":"Health and Technology Research Center (H&TRC), Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Instituto Polit\u00e9cnico de Lisboa, Lisbon, Portugal"},{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Lisbon, Portugal"},{"name":"NOVA Medical School\u2014Faculdade de Ci\u00eancias Medicas, New University of Lisbon, Lisbon, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"bibr1-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"bibr2-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7757"},{"key":"bibr3-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344083"},{"key":"bibr4-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4039"},{"key":"bibr5-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0029"},{"key":"bibr6-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800708105"},{"key":"bibr7-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.017"},{"key":"bibr8-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1007\/400_2007_049"},{"key":"bibr9-1177271920928923","doi-asserted-by":"publisher","DOI":"10.2174\/157015909787602779"},{"key":"bibr10-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031964"},{"key":"bibr11-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0363"},{"key":"bibr12-1177271920928923","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.12.3142"},{"key":"bibr13-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7873"},{"key":"bibr14-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.038737"},{"key":"bibr15-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1069"},{"key":"bibr16-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.03.001"},{"key":"bibr17-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0456"},{"key":"bibr18-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1159\/000358345"},{"key":"bibr19-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.10.002"},{"key":"bibr20-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04135.x"},{"key":"bibr21-1177271920928923","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1598"},{"key":"bibr22-1177271920928923","unstructured":"WHO Expert Committee. Physical status: the use and interpretation of anthropometry. WHO technical report series no. 854. Geneva, Switzerland: WHO, 1995."},{"key":"bibr23-1177271920928923","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"bibr24-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"bibr25-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-018-0599-6."},{"key":"bibr26-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2013.06.003"},{"key":"bibr27-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1159\/000346059"},{"key":"bibr28-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0375"},{"key":"bibr29-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.40"},{"key":"bibr30-1177271920928923","doi-asserted-by":"crossref","first-page":"377","DOI":"10.5603\/EP.2014.0052","volume":"65","author":"Dardzi\u0144ska JA","year":"2014","journal-title":"Endokrynol Pol"},{"key":"bibr31-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0183"},{"key":"bibr32-1177271920928923","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02601"}],"container-title":["Biomarker Insights"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1177271920928923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1177271920928923","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1177271920928923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:26:20Z","timestamp":1777382780000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/1177271920928923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":32,"alternative-id":["10.1177\/1177271920928923"],"URL":"https:\/\/doi.org\/10.1177\/1177271920928923","relation":{},"ISSN":["1177-2719","1177-2719"],"issn-type":[{"value":"1177-2719","type":"print"},{"value":"1177-2719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}