{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:37:38Z","timestamp":1754483858347,"version":"3.41.2"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cent Nerv Syst Dis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Multiple sclerosis treatment has changed in the last years with the emergence of new disease-modifying therapies (DMTs). Despite a better efficacy profile, these drugs raise concerns about infectious risk, which needs to be mitigated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p> To analyze the results of a systematic collaborative approach between Neurology and Infectious Diseases (ID) Departments in the management of infectious risk and complications in MS patients treated with DMT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Retrospective collection of MS patients\u2019 demographic and clinical data from clinical records of MS and ID outpatient clinics (2011\u20132017). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> We included 149 patients: most had evidence of previous contact with Herpesviridae, and half of them were not immune to hepatitis A and B viruses (HAV and HBV). Vaccines for HAV, HBV, and Streptococcus pneumoniae were administered in 91%, 78%, and 88% of non-immune patients, respectively. JC virus serology monitoring prevented natalizumab (NTZ) initiation or prompted its switch in 34\/122 patients. Forty patients had latent tuberculosis, in which 88% were treated. Infectious events occurred in 33 patients, mostly mild urinary, respiratory, and herpes virus group infections. Only three patients required inpatient care. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Facing the expansion of the new DMT, we highlight the benefits of an interdisciplinary approach for safer use of the chosen treatment. <\/jats:p><\/jats:sec>","DOI":"10.1177\/11795735211042188","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T12:15:02Z","timestamp":1631103302000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Infectious Risk Mitigation in Patients with Multiple Sclerosis under Disease-Modifying Therapies \u2013 the Experience of a Collaborative Neurology-Infectious Diseases Approach"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-3006","authenticated-orcid":false,"given":"Daniela","family":"Ferro","sequence":"first","affiliation":[{"name":"MS Clinic, Neurology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Faculty of Medicine of University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-1499","authenticated-orcid":false,"given":"Beatriz","family":"Prista-Le\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of University of Porto, Porto, Portugal"},{"name":"Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Andreia","family":"Costa","sequence":"additional","affiliation":[{"name":"MS Clinic, Neurology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Faculty of Medicine of University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2077-3356","authenticated-orcid":false,"given":"Andr\u00e9","family":"Silva-Pinto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of University of Porto, Porto, Portugal"},{"name":"Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"C\u00e2ndida","family":"Abreu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of University of Porto, Porto, Portugal"},{"name":"Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Maria Jos\u00e9","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"MS Clinic, Neurology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"FP-ENAS (UFP Energy, Environment and Health Research Unit), University Fernando Pessoa, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"bibr1-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2019.08.012"},{"key":"bibr2-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0800-8"},{"key":"bibr3-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.030"},{"key":"bibr4-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy174"},{"key":"bibr5-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.21"},{"key":"bibr6-11795735211042188","unstructured":"Tysabri [package Insert]. Badhoevedorp, Netherlands: Biogen Netherlands B.V. 2020."},{"key":"bibr7-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1177\/2055217319875467"},{"key":"bibr8-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50862"},{"key":"bibr9-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116426"},{"key":"bibr10-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.491"},{"key":"bibr11-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-339"},{"key":"bibr12-11795735211042188","unstructured":"Carvalho C, Rodrigues AL, Gomes B, et al. Tuberculose na Regi\u00e3o de Sa\u00fade do Norte (2017). Departamento de Sa\u00fade P\u00fablica, Administra\u00e7\u00e3o de Sa\u00fade da Regi\u00e3o de Sa\u00fade do Norte, I.P. 2020. [To be published official report]."},{"key":"bibr13-11795735211042188","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207687"}],"container-title":["Journal of Central Nervous System Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735211042188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795735211042188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795735211042188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T06:43:40Z","timestamp":1740811420000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795735211042188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":13,"alternative-id":["10.1177\/11795735211042188"],"URL":"https:\/\/doi.org\/10.1177\/11795735211042188","relation":{},"ISSN":["1179-5735","1179-5735"],"issn-type":[{"type":"print","value":"1179-5735"},{"type":"electronic","value":"1179-5735"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"11795735211042188"}}