{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T10:54:58Z","timestamp":1759056898024,"version":"3.38.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T00:00:00Z","timestamp":1243555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p> Background <\/jats:p><jats:p> Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA\u2013DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA\u2013A*02 and A*03 alleles has been described. <\/jats:p><jats:p> Objectives <\/jats:p><jats:p> We examined the influence of HLA\u2013A*02 and HLA\u2013A*03 in Portuguese patients with MS, independently of HLA\u2013DRB1*15 using a logistic regression model. <\/jats:p><jats:p> Conclusions <\/jats:p><jats:p> DRB1*15 increased the risk of developing MS and HLA\u2013A*02 decreased the risk. A*03 had no effect. To analyze if HLA\u2013A*02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found. <\/jats:p>","DOI":"10.1177\/1352458509104588","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T09:52:40Z","timestamp":1243590760000},"page":"771-774","source":"Crossref","is-referenced-by-count":19,"title":["Protective role of the HLA\u2013A*02 allele in Portuguese patients with multiple sclerosis"],"prefix":"10.1177","volume":"15","author":[{"given":"AM","family":"Silva","sequence":"first","affiliation":[{"name":"Departamento de Neurologia, Centro Hospitalar do Porto \u2013 Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"A","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"UMIB \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS-UP), Porto, Portugal"}]},{"given":"C","family":"Pereira","sequence":"additional","affiliation":[{"name":"UMIB \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS-UP), Porto, Portugal"}]},{"given":"E","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Centro Hospitalar do Porto \u2013 Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"C","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o, Centro de Gen\u00e9tica M\u00e9dica Jacinto de Magalh\u00e3es, Porto, Portugal"}]},{"given":"D","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Departamento do estudo de popula\u00e7\u00f5es, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS-UP), Porto, Portugal"}]},{"given":"PP","family":"Costa","sequence":"additional","affiliation":[{"name":"UMIB \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS-UP), Porto, Portugal; Unidade de Investiga\u00e7\u00e3o, Centro de Gen\u00e9tica M\u00e9dica Jacinto de Magalh\u00e3es, Porto, Portugal"}]},{"given":"L","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Centro Hospitalar do Porto \u2013 Hospital de Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"B","family":"Martins","sequence":"additional","affiliation":[{"name":"UMIB \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS-UP), Porto, Portugal; Unidade de Investiga\u00e7\u00e3o, Centro de Gen\u00e9tica M\u00e9dica Jacinto de Magalh\u00e3es, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2009,5,29]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90962-2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073493"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/ng2106"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.14"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000322"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.59"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.83"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.84"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/nature06010"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.550205.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-2815.2004.00173.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000664"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1399-0039.2007.00962.x","volume":"71","author":"Burfoot RK","year":"2008","journal-title":"Tissue Antigens"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.02.033"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi206"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl223"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21063"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364437"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1394.017"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh578"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458509104588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458509104588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T15:36:55Z","timestamp":1740843415000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458509104588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,29]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1177\/1352458509104588"],"URL":"https:\/\/doi.org\/10.1177\/1352458509104588","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"type":"print","value":"1352-4585"},{"type":"electronic","value":"1477-0970"}],"subject":[],"published":{"date-parts":[[2009,5,29]]}}}