{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:23:36Z","timestamp":1777937016997,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with paediatric-onset multiple sclerosis (POMS) could be at an increased risk for cognitive impairment (CI), given the potential harmful effects of disease activity in neurodevelopment. However, there is scarce information on their long-term cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare the prevalence and profile of CI between adults with a history of POMS and those with classic, adult-onset multiple sclerosis (AOMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cognitive performance was assessed through the Brief Repeatable Battery (BRB) and the Stroop Test in consecutive patients referred to six Italian MS centres. CI was defined as impairment in \u2a7e2 cognitive domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all, 119 patients with POMS and 712 with AOMS were included in this analysis. The prevalence of CI was 48.0% in AOMS, 44.5% in POMS; with similar neuropsychological profile between the two groups. However, when adjusting for current age, we found a significantly increased risk for CI (odds ratio (OR)\u2009=\u20091.71; p\u2009=\u20090.02) and for impairment in information processing speed (OR\u2009=\u20091.86; p\u2009&lt;\u20090.01) in patients with POMS. A higher Expanded Disability Status Scale (EDSS) was also identified in POMS ( p\u2009=\u20090.03) compared with AOMS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with a history of POMS appear to be at higher risk of physical and cognitive disability than AOMS patients, after correcting for age effects, with particular involvement of information processing speed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458517717341","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T12:02:01Z","timestamp":1498564921000},"page":"1234-1242","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Patients with paediatric-onset multiple sclerosis are at higher risk of cognitive impairment in adulthood: An Italian collaborative study"],"prefix":"10.1177","volume":"24","author":[{"given":"Luis","family":"Ruano","sequence":"first","affiliation":[{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, Porto, Portugal\/Departamento de Epidemiologia Clinica, Medicina Preditiva e Sa\u00fade P\u00fablica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal\/Neurology Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal"}]},{"given":"Mariana","family":"Branco","sequence":"additional","affiliation":[{"name":"Neurology Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal"}]},{"given":"Emilio","family":"Portaccio","sequence":"additional","affiliation":[{"name":"IRCCS \u2018Don Carlo Gnocchi\u2019, Florence, Italy"}]},{"given":"Benedetta","family":"Goretti","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA, Section Neurosciences, University of Florence, Florence, Italy"}]},{"given":"Claudia","family":"Niccolai","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA, Section Neurosciences, University of Florence, Florence, Italy"}]},{"given":"Francesco","family":"Patti","sequence":"additional","affiliation":[{"name":"University of Catania, Catania, Italy"}]},{"given":"Clara","family":"Chisari","sequence":"additional","affiliation":[{"name":"University of Catania, Catania, Italy"}]},{"given":"Paolo","family":"Gallo","sequence":"additional","affiliation":[{"name":"University of Padova, Padova, Italy"}]},{"given":"Paola","family":"Grossi","sequence":"additional","affiliation":[{"name":"University of Padova, Padova, Italy"}]},{"given":"Angelo","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Gallarate Hospital, Varese, Italy"}]},{"given":"Marco","family":"Roscio","sequence":"additional","affiliation":[{"name":"Gallarate Hospital, Varese, Italy"}]},{"given":"Flavia","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Spedali Civili Brescia, Brescia, Italy"}]},{"given":"Chiara","family":"Stampatori","sequence":"additional","affiliation":[{"name":"Spedali Civili Brescia, Brescia, Italy"}]},{"given":"Marta","family":"Simone","sequence":"additional","affiliation":[{"name":"Child and Adolescence Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy"}]},{"given":"Rosa Gemma","family":"Viterbo","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro, Bari, Italy"}]},{"given":"Maria Pia","family":"Amato","sequence":"additional","affiliation":[{"name":"Department NEUROFARBA, Section Neurosciences, University of Florence, Florence, 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