{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:01:32Z","timestamp":1778605292461,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Time matters in multiple sclerosis (MS). Irreversible neural damage and cell loss occur from disease onset. The MS community has endorsed a management strategy of prompt diagnosis, timely intervention and regular proactive monitoring of treatment effectiveness and disease activity to improve outcomes in people with MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We sought to develop internationally applicable quality standards for timely, brain health\u2013focused MS care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A panel of MS specialist neurologists participated in an iterative, online, modified Delphi process to define \u2018core\u2019, \u2018achievable\u2019 and \u2018aspirational\u2019 time frames reflecting minimum, good and high care standards, respectively. A multidisciplinary Reviewing Group (MS nurses, people with MS, allied healthcare professionals) provided insights ensuring recommendations reflected perspectives from multiple stakeholders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-one MS neurologists from 19 countries reached consensus on most core (25\/27), achievable (25\/27) and aspirational (22\/27) time frames at the end of five rounds. Agreed standards cover six aspects of the care pathway: symptom onset, referral and diagnosis, treatment decisions, lifestyle, disease monitoring and managing new symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These quality standards for core, achievable and aspirational care provide MS teams with a three-level framework for service evaluation, benchmarking and improvement. They have the potential to produce a profound change in the care of people with MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518809326","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T06:33:47Z","timestamp":1541054027000},"page":"1809-1818","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":85,"title":["International consensus on quality standards for brain health-focused care in multiple sclerosis"],"prefix":"10.1177","volume":"25","author":[{"given":"Jeremy","family":"Hobart","sequence":"first","affiliation":[{"name":"Plymouth University Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK"}]},{"given":"Amy","family":"Bowen","sequence":"additional","affiliation":[{"name":"NHS RightCare, NHS England, London, UK"}]},{"given":"George","family":"Pepper","sequence":"additional","affiliation":[{"name":"Shift.ms, Leeds, UK"}]},{"given":"Harriet","family":"Crofts","sequence":"additional","affiliation":[{"name":"PharmaGenesis London, London, UK"}]},{"given":"Lucy","family":"Eberhard","sequence":"additional","affiliation":[{"name":"PharmaGenesis London, London, UK"}]},{"given":"Thomas","family":"Berger","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}]},{"given":"Alexey","family":"Boyko","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, Moscow, Russia\/Demyelinating Diseases Center, Yusupov Hospital, Moscow, Russia"}]},{"given":"Cavit","family":"Boz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Karadeniz Technical University, Trabzon, Turkey"}]},{"given":"Helmut","family":"Butzkueven","sequence":"additional","affiliation":[{"name":"MS and Neuroimmunology Unit, Alfred Health and Eastern Health, Monash University, Melbourne, VIC, Australia"}]},{"given":"Elisabeth Gulowsen","family":"Celius","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway"}]},{"given":"Jelena","family":"Drulovic","sequence":"additional","affiliation":[{"name":"Department for Immune-Mediated Disorders of the Central Nervous System, Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}]},{"given":"Jos\u00e9","family":"Flores","sequence":"additional","affiliation":[{"name":"National Institute of Neurology and Neurosurgery, ABC Medical Center, Mexico City, Mexico"}]},{"given":"Dana","family":"Hor\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}]},{"given":"Christine","family":"Lebrun-Fr\u00e9nay","sequence":"additional","affiliation":[{"name":"CRCSEP Neurologie Pasteur 2, Universit\u00e9 C\u00f4te d\u2019Azur, Nice, France"}]},{"given":"Ruth Ann","family":"Marrie","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada"}]},{"given":"James","family":"Overell","sequence":"additional","affiliation":[{"name":"Glasgow MS Clinical Research Centre, Queen Elizabeth University Hospital, Glasgow, UK"}]},{"given":"Fredrik","family":"Piehl","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Peter Vestergaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aarhus University Hospital, Aarhus, Denmark"}]},{"given":"Maria Jos\u00e9","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"MS Clinic, Department of Neurology, Centro Hospitalar S\u00e3o Jo\u00e3o, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"Carmen-Adella","family":"S\u00eerbu","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, Central Military Emergency University Hospital, Bucharest, Romania"}]},{"given":"Eli","family":"Skromne","sequence":"additional","affiliation":[{"name":"Instituto Mexicano de Neurociencias, Hospital Angeles Lomas, Mexico City, Mexico"}]},{"given":"\u00d8ivind","family":"Torkildsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haukeland University Hospital, Bergen, Norway"}]},{"given":"Vincent","family":"van Pesch","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, 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