{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:39:13Z","timestamp":1777397953111,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR\u2009=\u20090.77, 95%CI 0.66\u20130.89, p\u2009&lt;\u20090.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR\u2009=\u20090.85, 95%CI 0.73\u20130.99, p\u2009=\u20090.029; OR\u2009=\u20090.62, 95%CI 0.45\u20130.86, p\u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251379083","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:08:47Z","timestamp":1763104127000},"page":"1043-1059","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of lifestyle factors with amyloid pathology in persons without dementia"],"prefix":"10.1177","volume":"108","author":[{"given":"Julie E","family":"Oomens","sequence":"first","affiliation":[{"name":"Alzheimer Center Limburg, Department of Psychiatry &amp; Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands"}]},{"given":"Stephanie JB","family":"Vos","sequence":"additional","affiliation":[{"name":"Alzheimer Center Limburg, Department of Psychiatry &amp; Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands"}]},{"given":"Nancy N","family":"Maserejian","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biogen, Cambridge, MA, USA"}]},{"given":"Merc\u00e8","family":"Boada","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona \u2013 Universitat Internacional de Catalunya, Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"}]},{"given":"Mira","family":"Didic","sequence":"additional","affiliation":[{"name":"APHM, Timone, Service de Neurologie et Neuropsychologie, H\u00f4pital Timone Adultes, Marseille, France"},{"name":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Jardin du Pharo, Marseille, France"}]},{"given":"Sebastiaan","family":"Engelborghs","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium"},{"name":"NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium"}]},{"given":"Tormod","family":"Fladby","sequence":"additional","affiliation":[{"name":"Department of Neurology, Akershus University Hospital, Lorenskog, Norway"}]},{"given":"Wiesje M","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands"}]},{"given":"Giovanni B","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Memory Clinic, University Hospitals and University of Geneva, Geneva, Switzerland"}]},{"given":"Lutz","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany"}]},{"given":"Kiran Dip","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}]},{"given":"Timo","family":"Grimmer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany"}]},{"given":"Jakub","family":"Hort","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}]},{"given":"Yoshiaki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}]},{"given":"Takeshi","family":"Iwatsubo","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan"}]},{"given":"Aleksandra","family":"Klimkowicz-Mrowiec","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland"}]},{"given":"Susan M","family":"Landau","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA"}]},{"given":"Dong Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"},{"name":"Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}]},{"given":"Pablo","family":"Martinez-Lage","sequence":"additional","affiliation":[{"name":"Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, Donostia-San Sebastian, Spain"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon, Lisboa, Portugal"}]},{"given":"Philipp T","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}]},{"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[{"name":"Istituto delle Scienze Neurologiche di Bologna, IRCCS, Padiglione G, Bologna, Italy"},{"name":"Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy"}]},{"given":"Matteo","family":"Pardini","sequence":"additional","affiliation":[{"name":"DINOGMI, University of Genoa, Genoa, Italy"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Centro Disturbi della Memoria, Laboratorio di Neurochimica Clinica, Clinica Neurologica, Universit\u00e0 di Perugia, Perugia, Italy"}]},{"given":"Julius","family":"Popp","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, University Hospital of Psychiatry Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland"},{"name":"Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland"}]},{"given":"Lorena","family":"Rami","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic of Barcelona, IDIBAPS, Barcelona, 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and Cell Biology - CIBB, University of Coimbra, Coimbra, Portugal"},{"name":"Neurology Department and Laboratory of Neurochemistry, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Nikolaos","family":"Scarmeas","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece"},{"name":"Department of Neurology, Columbia University, New York City, NY, USA"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}]},{"given":"Ingmar","family":"Skoog","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"}]},{"given":"Reisa A","family":"Sperling","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Harvard Aging Brain Study, Department of Neurology, Harvard Medical School, Boston, MA, USA"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division, Department of Neurology and the Taub Institute, Columbia, New York City, NY, USA"}]},{"given":"Sylvia","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada"},{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"}]},{"given":"Gunhild","family":"Waldemar","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of T\u00fcbingen, T\u00fcbingen, Germany"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"},{"name":"Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, UK"},{"name":"UK Dementia Research Institute, London, UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Hongkong, China"},{"name":"Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA"}]},{"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"},{"name":"Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}]},{"given":"Ricardo F","family":"Allegri","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology, Instituto Neurol\u00f3gico Fleni, Buenos Aires, 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Portugal"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}]},{"given":"Anouk den","family":"Braber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}]},{"given":"Mark A","family":"van Buchem","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Leiden is the institution, Leiden, the Netherlands"}]},{"given":"Min Soo","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"}]},{"given":"Ji\u0159\u00ed","family":"Cerman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute, Phoenix, AZ, USA"}]},{"given":"Elena","family":"Chipi","sequence":"additional","affiliation":[{"name":"Centro Disturbi della Memoria, Laboratorio di Neurochimica Clinica, Clinica Neurologica, Universit\u00e0 di Perugia, Perugia, Italy"}]},{"given":"Gregory S","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic in Florida, Jacksonville, FL, USA"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany"}]},{"given":"Laura L","family":"Ekblad","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Department of Geriatrics, Turku University Hospital, Wellbeing services county of Southwestern Finland, Turku, Finland"}]},{"given":"Stefan","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany"},{"name":"Department of Nuclear Medicine, Klinikum Bayreuth, Bayreuth, Germany"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"},{"name":"Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}]},{"given":"Yvonne","family":"Freund-Levi","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden"},{"name":"Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden"},{"name":"Department of Old Age Psychiatry, Psychology and Neuroscience, King's College, London, UK"}]},{"given":"Lars","family":"Frings","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}]},{"given":"Eric","family":"Guedj","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Aix Marseille University, AP-HM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, Centre Europ\u00e9en de Recherche en Imagerie M\u00e9dicale (CERIMED), Marseille, France"}]},{"given":"Christian G","family":"Habeck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA"}]},{"given":"Ron","family":"Handels","sequence":"additional","affiliation":[{"name":"Alzheimer Center Limburg, Department of Psychiatry &amp; Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands"}]},{"given":"Lucrezia","family":"Hausner","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany"}]},{"given":"Sabine","family":"Hellwig","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}]},{"given":"Julio F","family":"Jim\u00e9nez-Bonilla","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Marqu\u00e9s de Valdecilla University Hospital and IDIVAL, Santander, Spain"}]},{"given":"Ane Iriondo","family":"Juaristi","sequence":"additional","affiliation":[{"name":"Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, Donostia-San Sebastian, Spain"}]},{"given":"Ramesh","family":"Kandimalla","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA, USA"},{"name":"Applied Biology, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India"},{"name":"Department of Biochemistry, Kakatiya Medical College\/Mahatma Gandhi Memorial Hospital, Warangal, Telangana State, India"}]},{"given":"Silke","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Department of Psychiatry, Cognition and Old Age Psychiatry, Sahlgrenska University Hospital, V\u00e4stra G\u00f6talandsregion, Sweden"}]},{"given":"Bj\u00f8rn-Eivind S","family":"Bordewick Kirsebom","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of North Norway, Troms\u00f8, Norway"},{"name":"Department of Psychology, The Arctic University of Norway, Troms\u00f8, Norway"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany"}]},{"given":"Nienke","family":"Legdeur","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases, site Munich, Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany"}]},{"given":"Marta","family":"Marqui\u00e9","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona \u2013 Universitat Internacional de Catalunya, Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"}]},{"given":"Shinobu","family":"Minatani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}]},{"given":"Silvia Daniela","family":"Morbelli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy"},{"name":"Ospedale Policlinico San Martino, IRCCS, Genoa, 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Madrid, Spain"}]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin-CBF, Berlin, Germany"}]},{"given":"Sudesh","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}]},{"given":"Inez H","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Alzheimer Center Limburg, Department of Psychiatry &amp; Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands"}]},{"given":"Eloy","family":"Rodr\u00edguez-Rodriguez","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Universitario Marqu\u00e9s de Valdecilla and IDIVAL, University of Cantabria, Santander, CIBERNED, Madrid, Santander, Spain"}]},{"given":"Agust\u00edn","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Ace 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Portugal"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopia, Finland"}]},{"given":"Luiza","family":"Spiru","sequence":"additional","affiliation":[{"name":"Geriatrics, Gerontology, Old Age Psychiatry, Geroscience, Gerontechnology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"Excellence Center for Memory Diseases, Brain Health and Longevity Medicine \u2013 Ana Aslan International Foundation, Bucharest, Romania"}]},{"given":"Akitoshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}]},{"given":"Charlotte E","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Lab, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}]},{"given":"Betty M","family":"Tijms","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}]},{"given":"Lisa","family":"Vermunt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}]},{"given":"\u00c5sa K","family":"Wallin","sequence":"additional","affiliation":[{"name":"Cognitive disorder research unit, Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}]},{"given":"Wietse","family":"Wiels","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, 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