{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:37:20Z","timestamp":1793090240555,"version":"4.5.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Changping Laboratory","award":["2025B-07-32"],"award-info":[{"award-number":["2025B-07-32"]}],"id":[{"id":"https:\/\/ror.org\/04kf84k17","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20753"],"award-info":[{"award-number":["U24A20753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L252089"],"award-info":[{"award-number":["L252089"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age-related impairments in cerebrovascular reactivity (CVR) and gray matter volume (GMV) both contribute to cognitive decline, yet their regional interplay and joint impact on cognition remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate how CVR and GMV are coupled and interact regionally to influence cognition in normal aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined 181 healthy younger adults (18\u201334 years) and 120 older adults (60\u201389 years). CVR and GMV (% intracranial volume) in major brain lobes were quantified using resting-state multi-echo functional MRI and structural MRI, respectively. Age-related alterations were defined by standardizing older adults\u2019 values relative to the younger group. Spearman correlations, linear regression models, and interaction analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CVR and GMV were not significantly correlated across frontal, temporal, parietal, or occipital lobes (\u03c1: \u22120.15 to \u22120.06; all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, significant CVR \u00d7 GMV interaction effects on executive function were found in parietal and occipital lobes (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -interaction=0.015 and 0.026). In the occipital lobe, compared with the \u201clow CVR decline + low GMV loss\u201d group, \u201chigh CVR decline + low GMV loss\u201d (\u03b2=\u22120.47,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004) and \u201chigh CVR decline + high GMV loss\u201d (\u03b2=\u22120.60,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not \u201clow CVR decline + high GMV loss\u201d (\u03b2=\u22120.23,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.127), were significantly associated with poorer executive function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CVR and GMV interacted to support executive function in parietal and occipital lobes. Occipital CVR decline linked to poorer executive performance irrespective of GMV status. These findings highlight the importance of multi-modal, cross-scale assessments and suggest CVR as a sensitive marker of executive decline beyond structural measures alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261487149","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:04:57Z","timestamp":1790604297000},"page":"227-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic effects of cerebrovascular reactivity and gray matter volume on executive function in aging"],"prefix":"10.1177","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-9015","authenticated-orcid":false,"given":"Jiajia","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University"},{"name":"Key Laboratory of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-2245","authenticated-orcid":false,"given":"Xuejia","family":"Jia","sequence":"additional","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University"},{"name":"Key Laboratory of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-7287","authenticated-orcid":false,"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[{"name":"GE Healthcare MR Research, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7043-3471","authenticated-orcid":false,"given":"Qihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University"},{"name":"Key Laboratory of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0830-5960","authenticated-orcid":false,"given":"Peiying","family":"Liu","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine"},{"name":"Department of Diagnostic Radiology &amp; 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