{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:02Z","timestamp":1792787702342,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Center for Advancing Translational Sciences of the National Institutes of Health","award":["TL1TR00236 and UL1TR002366"],"award-info":[{"award-number":["TL1TR00236 and UL1TR002366"]}],"id":[{"id":"https:\/\/ror.org\/04pw6fb54","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institutes of Health","award":["R01 AG060157"],"award-info":[{"award-number":["R01 AG060157"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Apolipoprotein E \u03b54 (\n                      <jats:italic toggle=\"yes\">APOE4)<\/jats:italic>\n                      carriers with cognitive impairment exhibit lower BMI than non-carriers, but whether\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      influences body composition in cognitively normal older adults remains unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To examine the association between\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status and body composition in cognitively normal older adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cross-sectional analysis of 203 cognitively normal older adults (mean age 71.4\u2009\u00b1\u20094.8 years). Body composition was assessed via dual-energy x-ray absorptiometry. Linear regression models adjusted for age, sex, total energy intake, and physical activity examined associations between\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      status and BMI, body fat percentage, fat mass index (FMI), and lean mass index (LMI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers (32%, n\u2009=\u200965) had lower BMI (\u03b2\u2009=\u2009\u22121.42\u2005kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , p\u2009=\u20090.043), body fat percentage (\u03b2\u2009=\u2009\u22123.56%, p\u2009&lt;\u20090.001), and FMI (\u03b2\u2009=\u2009\u22121.51\u2005kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , p\u2009=\u20090.002) compared to non-carriers (68%, n\u2009=\u2009138). LMI did not differ between groups (\u03b2\u2009=\u20090.18\u2005kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , p\u2009=\u20090.43).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers exhibited lower adiposity but not lean mass compared to non-carriers, independent of total energy intake and physical activity. These findings suggest\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      influences fat mass through metabolic mechanisms that emerge before cognitive decline. Longitudinal studies are needed to determine whether these differences contribute to AD pathogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261493064","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:15:45Z","timestamp":1790828145000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>APOE4<\/i>\n                    is associated with lower adiposity independent of total energy intake in cognitively normal older adults"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-8365","authenticated-orcid":false,"given":"Aaron N.","family":"Smith","sequence":"first","affiliation":[{"name":"University of Kansas Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Kansas Medical 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